Ulcova-Gallova Zdenka
Genetics-Pilsen Charles University Pilsen Czech Republic.
Department of Gynecology and Obstetrics Charles University Pilsen Czech Republic.
Reprod Med Biol. 2014 Oct 7;14(2):49-55. doi: 10.1007/s12522-014-0196-y. eCollection 2015 Apr.
Antiphospholipid antibodies (aPls) are generally characterized as heterogeneous and non-specific autoantibodies directed against various phospholipids such as cardiolipin, ph-serine, ph-inositol, ph-acid, ph-glycerol, ph-sphyngomyelin, ph-choline, annexins, and co-factor β2-glycoprotein I. aPls occur not only during autoimmune diseases but also during infectious diseases, essential hypertension, neurological complication, metabolic diseases, some drug abuse, and transplant loss. aPls are very often found in connection with reproductive failure such as repeated pregnancy loss and/or missed abortion, intrauterine fetal death, in preeclampsia, and repeated delivery of hypothrophic fetus. The presence of aPls, thrombosis, and fertility failure create primary or secondary antiphospholipid syndrome. This article explains some aspects and clinical and laboratory significance of the aPls in female infertility.
抗磷脂抗体（aPls）通常被认为是针对多种磷脂的异质性非特异性自身抗体，这些磷脂包括心磷脂、磷脂酰丝氨酸、磷脂酰肌醇、磷脂酸、磷脂甘油、鞘磷脂、磷脂胆碱、膜联蛋白以及辅因子β2-糖蛋白I。aPls不仅在自身免疫性疾病中出现，还见于感染性疾病、原发性高血压、神经系统并发症、代谢性疾病、一些药物滥用情况以及移植失败时。aPls常常与生殖功能衰竭相关，如反复流产和/或稽留流产、宫内胎儿死亡、先兆子痫以及低体重儿的反复分娩。aPls的存在、血栓形成和生育能力衰竭构成了原发性或继发性抗磷脂综合征。本文阐述了aPls在女性不孕症中的一些方面以及临床和实验室意义。
