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睾丸间质细胞瘤，表现为无精子症。

Leydig cell tumor of the testis, presenting with azoospermia.

作者信息

Hibi Hatsuki, Yamashita Kyoko, Sumitomo Makoto, Asada Yoshimasa

机构信息

Department of Urology Kyoritsu General Hospital Nagoya Japan.

Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine Nagoya Japan.

出版信息

Reprod Med Biol. 2017 Jul 20;16(4):392-395. doi: 10.1002/rmb2.12046. eCollection 2017 Oct.

DOI:10.1002/rmb2.12046
PMID:29259494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5715892/
Abstract

CASE

A case of Leydig cell tumor, associated with azoospermia, is presented.

OUTCOME

The levels of sex hormones obviously were decreased, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH), with elevated testosterone. Computed tomography revealed no adrenal gland tumor, but a significant calcification in the right scrotal content was observed. He received a right radical orchiectomy and then he was unable to ejaculate. An endocrine panel revealed significantly decreased levels of testosterone and the low LH level had remained. Hormone replacement therapy with combined LH and FSH successfully recovered and preserved spermatogenesis.

CONCLUSIONS

Although the patient's sexual function deteriorated after surgery, hormone replacement therapy was successful in establishing spermatogenesis.

摘要

病例

报告一例与无精子症相关的睾丸间质细胞瘤。

结果

性激素水平明显降低，包括促黄体生成素（LH）和促卵泡生成素（FSH），而睾酮升高。计算机断层扫描未发现肾上腺肿瘤，但观察到右侧阴囊内容物有明显钙化。他接受了右侧根治性睾丸切除术，术后无法射精。内分泌检查显示睾酮水平显著降低，LH水平仍然较低。联合使用LH和FSH的激素替代疗法成功恢复并保留了精子发生。

结论

尽管患者术后性功能恶化，但激素替代疗法成功地建立了精子发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d8/5715892/808907c5cdd9/RMB2-16-392-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d8/5715892/5becdcdddbcc/RMB2-16-392-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d8/5715892/1338ccb085df/RMB2-16-392-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d8/5715892/808907c5cdd9/RMB2-16-392-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d8/5715892/5becdcdddbcc/RMB2-16-392-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d8/5715892/1338ccb085df/RMB2-16-392-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03d8/5715892/808907c5cdd9/RMB2-16-392-g003.jpg

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本文引用的文献

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Leydig cell tumor of the testis with azoospermia and elevated delta4 androstenedione: case report.睾丸间质细胞瘤伴无精子症及δ4雄烯二酮升高：病例报告
Basic Clin Androl. 2016 Nov 8;26:14. doi: 10.1186/s12610-016-0041-8. eCollection 2016.
2
Leydig cell tumors of the testis: a case report.睾丸间质细胞瘤：一例报告
BMC Res Notes. 2014 Sep 18;7:656. doi: 10.1186/1756-0500-7-656.
3
[Testicular Leydig cell tumor presenting as male infertility: a case report].[以男性不育为表现的睾丸间质细胞瘤：一例报告]
睾丸支持细胞瘤伴无精子症：一例报告及文献复习
Medicine (Baltimore). 2020 Sep 4;99(36):e22085. doi: 10.1097/MD.0000000000022085.
4
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Int J Mol Sci. 2020 May 21;21(10):3649. doi: 10.3390/ijms21103649.
Hinyokika Kiyo. 2009 Dec;55(12):777-81.
4
Unilateral malignant leydig cell tumor of testis in a patient with contralateral cryptorchidism.一名对侧隐睾患者的单侧睾丸恶性莱迪希细胞瘤。
Urol J. 2009 Winter;6(1):60-2.
5
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J Urol. 2007 Sep;178(3 Pt 1):872-6; quiz 1129. doi: 10.1016/j.juro.2007.05.077. Epub 2007 Jul 16.
6
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Hum Reprod. 2007 Apr;22(4):1068-72. doi: 10.1093/humrep/del468. Epub 2006 Dec 15.
7
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Pathol Int. 2001 Oct;51(10):792-6. doi: 10.1046/j.1440-1827.2001.01278.x.
8
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