吲哚 - 3 - 羧酸酯的简洁流动合成及其向生长素类似物的衍生化。
A concise flow synthesis of indole-3-carboxylic ester and its derivatisation to an auxin mimic.
作者信息
Baumann Marcus, Baxendale Ian R, Deplante Fabien
机构信息
Department of Chemistry, University of Durham, South Road, Durham, Durham, DH1 3LE, UK.
出版信息
Beilstein J Org Chem. 2017 Nov 29;13:2549-2560. doi: 10.3762/bjoc.13.251. eCollection 2017.
Abstract
An assembled suite of flow-based transformations have been used to rapidly scale-up the production of a novel auxin mimic-based herbicide which was required for preliminary field trials. The overall synthetic approach and optimisation studies are described along with a full description of the final reactor configurations employed for the synthesis as well as the downstream processing of the reaction streams.
摘要
一套基于流程的组合转化方法已被用于快速扩大一种新型生长素类似物除草剂的生产规模，该除草剂是初步田间试验所必需的。文中描述了整体合成方法和优化研究，以及对合成中使用的最终反应器配置和反应物流下游处理的完整描述。
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