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杂环化合物的连续流合成：吲哚的流动合成最新进展。

Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles.

机构信息

Flow Chemistry and Microreactor Technology FLAME-Lab, Department of Pharmacy-Drug Sciences, University of Bari "A. Moro" Via E. Orabona 4, 70125 Bari, Italy.

出版信息

Molecules. 2020 Jul 16;25(14):3242. doi: 10.3390/molecules25143242.

DOI:10.3390/molecules25143242
PMID:32708643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7397031/
Abstract

Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis. In this review, the role of flow technology in the preparation of indole derivatives is showcased. Selected examples have been described with the aim to provide readers with an overview on the tactics and technologies used for targeting indole scaffolds.

摘要

吲哚衍生物是药物发现和药物化学中应用最广泛、最有趣的杂环之一。此外，流动化学和流动技术正在改变现代合成领域的合成范式。在这篇综述中，展示了流动技术在吲哚衍生物制备中的作用。选择了一些例子来说明，旨在为读者提供针对吲哚骨架的策略和技术的概述。

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