Paschkowsky Sandra, Oestereich Felix, Munter Lisa Marie
Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 0B1, Canada.
J Membr Biol. 2018 Jun;251(3):369-378. doi: 10.1007/s00232-017-0008-5. Epub 2017 Dec 19.
Proteases, sharp yet unforgivable tools of every cell, require tight regulation to ensure specific non-aberrant cleavages. The relatively recent discovered class of intramembrane proteases has gained increasing interest due to their involvement in important signaling pathways linking them to diseases including Alzheimer's disease and cancer. Despite tremendous efforts, their regulatory mechanisms have only started to unravel. There is evidence that the membrane composition itself can regulate intramembrane protease activity and specificity. In this review, we highlight the work on γ-secretase and rhomboid proteases and summarize several studies as to how different lipids impact on enzymatic activity.
蛋白酶是每个细胞中锐利而不容出错的工具，需要严格调控以确保特定的、无误的切割。相对较新发现的一类膜内蛋白酶因其参与重要信号通路并与包括阿尔茨海默病和癌症在内的疾病相关联而受到越来越多的关注。尽管付出了巨大努力，它们的调控机制才刚刚开始被揭示。有证据表明膜的组成本身可以调节膜内蛋白酶的活性和特异性。在这篇综述中，我们重点介绍了γ-分泌酶和类菱形蛋白酶的研究工作，并总结了几项关于不同脂质如何影响酶活性的研究。
