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胸椎间盘源性综合征

Thoracic Discogenic Syndrome

作者信息

Fogwe Delvise T., Petrone Brandon, Munakomi Sunil, Mesfin Fassil B.

机构信息

University of Missouri

Northwell Health/Plainview Hospital

Abstract

Symptomatic thoracic discogenic syndrome poses a diagnostic challenge due to its rarity. The relative immobility of the thoracic spine due to its particular orientation, structure, and function in the vertebral column contributes to the rarity of thoracic discogenic syndrome. At birth, the thoracic spine and sacrum exhibit a kyphotic curvature, whereas the cervical and lumbar spine develop full lordosis around puberty. The lordotic nature of the cervical and lumbar spine enables them to bear most of the axial skeleton's weight compared to the thoracic and sacral spine. As a result, the latter regions are less prone to disk degeneration and subsequent discogenic pain syndromes. Except for the atlas and axis, between each vertebral body lies an intervertebral disk. These disks consist of the outer rigid fibrous ring, known as annulus fibrosis, an inner soft gelatinous core called the nucleus pulposus, and the vertebral endplates. The vertebral endplates lie on the superior and inferior aspects of the disks next to the vertebral bodies and aid in the diffusion of nutrients into the disks. The intervertebral disks absorb shock and allow flexibility of the vertebral column. As the body ages, the integrity of these disks declines, potentially leading to the protrusion of the nucleus pulposus through the outer layer. Affected patients may experience corresponding nerve root or spinal cord compression, leading to radicular or myelopathic symptoms. Although degeneration is the primary cause of thoracic disk disease, trauma accounts for a small percentage of injuries to this area. Patients may either remain asymptomatic or present with pain that can progress to radiculopathy or myelopathy. Many of the symptoms are nonspecific, and the pain is highly dependent on the location of the herniated disk. Patients may experience pain in various regions, such as the chest wall, epigastric area, upper extremities, groin, or lower extremities, leading to a broad range of differential diagnoses. Confirmation of the diagnosis is made using magnetic resonance imaging (MRI). Asymptomatic thoracic disk herniations are common incidental findings on MRI scans. The mainstay of therapy for thoracic discogenic pain syndrome is conservative, with a focus on posture, body mechanics, muscle strengthening, and prevention. Surgical intervention becomes necessary in cases where patients exhibit myelopathic signs or when severe pain persists despite conservative treatment measures. However, performing a diskectomy in the thoracic spine presents unique challenges. The spinal canal is relatively narrow in the thoracic spine, and the thecal sac cannot be manipulated as freely as it can within the lumbar region. Therefore, the operative approach must minimize manipulation of the dura and spinal cord. Various procedures are available, each with its advantages and disadvantages.

摘要

有症状的胸椎源性综合征因其罕见性而带来诊断挑战。胸椎在脊柱中的特定方向、结构和功能导致其相对活动度较低,这使得胸椎源性综合征较为罕见。出生时,胸椎和骶骨呈后凸弯曲,而颈椎和腰椎在青春期前后发育出完全的前凸。颈椎和腰椎的前凸性质使它们相较于胸椎和骶骨能承受大部分轴向骨骼的重量。因此,后两个区域较少发生椎间盘退变及随后的椎间盘源性疼痛综合征。除寰椎和枢椎外,每个椎体之间都有一个椎间盘。这些椎间盘由外部坚硬的纤维环(即纤维环)、内部柔软的胶状核心(称为髓核)以及椎体终板组成。椎体终板位于椎间盘紧邻椎体的上、下表面,有助于营养物质扩散到椎间盘内。椎间盘起到吸收冲击并使脊柱具有灵活性的作用。随着身体衰老,这些椎间盘的完整性下降,可能导致髓核突出穿过外层。受影响的患者可能会出现相应的神经根或脊髓受压,导致神经根性或脊髓病症状。虽然退变是胸椎疾病的主要原因,但创伤在该区域损伤中占比很小。患者可能无症状,也可能出现疼痛,疼痛可能进展为神经根病或脊髓病。许多症状是非特异性的,疼痛高度取决于椎间盘突出的位置。患者可能在胸壁、上腹部、上肢、腹股沟或下肢等不同区域出现疼痛,导致广泛的鉴别诊断。通过磁共振成像(MRI)来确认诊断。无症状的胸椎间盘突出是MRI扫描中常见的偶然发现。胸椎源性疼痛综合征的主要治疗方法是保守治疗,重点在于姿势、身体力学、肌肉强化和预防。在患者出现脊髓病体征或尽管采取了保守治疗措施但仍有严重疼痛持续存在的情况下,手术干预就变得必要。然而,在胸椎进行椎间盘切除术存在独特的挑战。胸椎的椎管相对狭窄,硬膜囊不像在腰椎区域那样可以自由操作。因此,手术入路必须尽量减少对硬脑膜和脊髓的操作。有多种手术方法可供选择,每种方法都有其优缺点。

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