Moin Ayesha, Shetty Akshay D
Department of Oral and Maxillofacial Surgery, Sri Rajiv Gandhi College of Dental Sciences, Bengaluru, Karnataka, India.
Ann Maxillofac Surg. 2017 Jul-Dec;7(2):312-315. doi: 10.4103/ams.ams_85_17.
Malignant lymphomas form a heterogeneous group of neoplasms of the lymphoid tissue with different clinical courses, depending on the treatment and prognosis. Lymphoma is a malignant neoplasm of the lymphoid tissue; it is broadly classified into Hodgkin lymphoma (HL) and Non-HL (NHL) depending on the presence or absence of the Reed-Sternberg cells. The main types of lymphomas are (1) HL and (2) NHL. This case report describes about primary NHL involving the mandible. Chemotherapy was advised by the oncologist, and a total of 14 cycles were suggested at the gap of every 2 weeks. The treatment regimen followed was classical Cyclophosphamide hydrodaunorubicin oncovin Prednisolone (CHOP) therapy. NHL can be managed by chemotherapy, radiotherapy, and surgery in various combinations. NHL arising in bone is best treated by chemotherapy and may not require radiotherapy. Survival and prognosis are excellent in localized disease, whereas disseminated disease seems less favorable.
恶性淋巴瘤是一组异质性的淋巴组织肿瘤，其临床病程各异，取决于治疗方法和预后。淋巴瘤是淋巴组织的恶性肿瘤；根据里德-斯腾伯格细胞的有无，大致分为霍奇金淋巴瘤（HL）和非霍奇金淋巴瘤（NHL）。淋巴瘤的主要类型有（1）HL和（2）NHL。本病例报告描述了累及下颌骨的原发性NHL。肿瘤学家建议进行化疗，每2周进行1次，共建议进行14个周期。采用的治疗方案是经典的环磷酰胺、阿霉素、长春新碱、泼尼松（CHOP）疗法。NHL可以通过化疗、放疗和手术的各种组合进行治疗。发生于骨骼的NHL最好通过化疗进行治疗，可能不需要放疗。局限性疾病的生存率和预后良好，而播散性疾病的预后似乎较差。
