Shmidt T E
Sechenov First Moscow State Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(11):140-145. doi: 10.17116/jnevro2017117111140-145.
Dimethyl fumarate (DMF) is a new oral option for disease-modifying therapy (DMT) in patients with remitting multiple sclerosis as a first line treatment. The results of international randomized studies comparing DMF with placebo and other DMTs are presented. DMF is a DMT with promised efficacy and favorable safety profile that could be a treatment option for patients with suboptimal response for other first line DMTs and used as initial therapy for treatment-naive patients with unfavorable prognostic factors.
富马酸二甲酯(DMF)是缓解型多发性硬化症患者疾病修饰治疗(DMT)的一种新的口服一线治疗选择。文中展示了将DMF与安慰剂及其他DMT进行比较的国际随机研究结果。DMF是一种具有有望疗效和良好安全性的DMT,对于其他一线DMT反应欠佳的患者而言,它可以作为一种治疗选择,对于有不良预后因素的初治患者也可作为初始治疗方法。