Chusyd Daniella E, Brown Janine L, Hambly Catherine, Johnson Maria S, Morfeld Kari, Patki Amit, Speakman John R, Allison David B, Nagy Tim R
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Obesity (Silver Spring). 2018 Jan;26(1):103-110. doi: 10.1002/oby.22046.
The majority of zoo African elephants exhibit abnormal reproductive cycles, but it is unclear why. Acyclicity has been positively associated with body condition scores. The objective of this study was to measure body composition and examine the relationship between adiposity and cyclicity status, mediated by glucose, insulin, leptin, and inflammation.
Body composition was assessed by deuterium dilution in 22 African elephants. Each elephant was weighed and given deuterated water orally (0.05 mL/kg), and blood was collected from the ear prior to and five times after deuterium administration. Glucose, insulin, leptin, and proinflammatory biomarker concentrations in serum were determined.
Body fat percentage ranged from 5.24% to 15.97%. Fat adjusted for fat free mass (FFM) and age was not significantly associated with cyclicity status (P = 0.332). Age was the strongest predictor of cyclicity status (P = 0.040). Fat was correlated with weight (ρ = 0.455, P = 0.044) and when adjusted for FFM with circulating glucose (ρ = 0.520, P = 0.022) and showed a trend for association with leptin (unadjusted: ρ = 0.384, P = 0.095; adjusted for FFM: ρ = 0.403, P = 0.087).
Deuterium dilution appears to be an available technique to measure body composition in African elephants. In this sample, fat was not associated with cyclicity status, and age may be more important to cyclicity status.
大多数动物园中的非洲象表现出异常的生殖周期，但原因尚不清楚。无排卵周期与身体状况评分呈正相关。本研究的目的是测量身体成分，并研究由葡萄糖、胰岛素、瘦素和炎症介导的肥胖与排卵周期状态之间的关系。
通过氘稀释法对22头非洲象的身体成分进行评估。每头大象称重后口服氘水（0.05 mL/kg），在给予氘水之前和之后采集5次耳部血液。测定血清中葡萄糖、胰岛素、瘦素和促炎生物标志物的浓度。
体脂百分比范围为5.24%至15.97%。调整了去脂体重（FFM）和年龄后的脂肪与排卵周期状态无显著相关性（P = 0.332）。年龄是排卵周期状态的最强预测因子（P = 0.040）。脂肪与体重相关（ρ = 0.455，P = 0.044），调整FFM后与循环葡萄糖相关（ρ = 0.520，P = 0.022），并且与瘦素有相关趋势（未调整：ρ = 0.384，P = 0.095；调整FFM后：ρ = 0.403，P = 0.087）。
氘稀释法似乎是一种可用于测量非洲象身体成分的技术。在本样本中，脂肪与排卵周期状态无关，而年龄对排卵周期状态可能更为重要。
