Bhamb Neil, Kanim Linda, Maldonado Ruben, Svet Mark, Metzger Melodie
Cedars-Sinai Medical Center, 444 S San Vicente Blvd, Suite 603, Los Angeles, California, 90048.
Translational and Clinical Research, Spine Center, Cedars-Sinai Medical Center, 444 S San Vicente Blvd, Suite 901, Los Angeles, California, 90048.
J Orthop Res. 2018 May;36(5):1435-1443. doi: 10.1002/jor.23832. Epub 2018 Jan 16.
Vitamin D plays a significant role in musculoskeletal health by regulating calcium, phosphate, and promoting new bone mineralization. The purpose of this study was to understand the effect of dietary vitamin D on general bone health during peri-operative bone healing via an in vivo dosing study of vitamin D in a rat posterolateral fusion model using autograft. Vitamin D Deficient (DD), vitamin D Insufficient (ID), Control vitamin D (CD), and Hyper-vitamin D (HD) groups were studied. Increasing dietary vitamin D improved quantitative measures of femoral geometry, including femoral strength, stiffness, and density. Femoral biomechanics, cortical thickness, moment of inertia, cross-sectional area, and measures from bone ashing were all greater in the HD group versus the CD. This suggests that additional dietary vitamin D above normal levels during spinal fusion may lead to improvement in bone health. Serum vitamin D levels were also observed to decrease during fusion healing. These results demonstrate that dietary vitamin D improves general bone health in the femur of a rat model during posterolateral spinal fusion. This suggests a role for further clinical evaluation of vitamin D dietary intake during the peri-operative period, with the possibility of avoiding adverse consequences to general bone health. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1435-1443, 2018.
维生素D通过调节钙、磷以及促进新的骨矿化，在肌肉骨骼健康中发挥着重要作用。本研究的目的是通过在大鼠后外侧融合模型中使用自体骨移植进行维生素D的体内给药研究，来了解围手术期骨愈合过程中膳食维生素D对总体骨骼健康的影响。研究了维生素D缺乏（DD）组、维生素D不足（ID）组、对照维生素D（CD）组和高维生素D（HD）组。增加膳食维生素D可改善股骨几何结构的定量指标，包括股骨强度、刚度和密度。HD组的股骨生物力学、皮质厚度、惯性矩、横截面积以及骨灰化测量值均高于CD组。这表明在脊柱融合过程中，高于正常水平的额外膳食维生素D可能会改善骨骼健康。在融合愈合过程中还观察到血清维生素D水平下降。这些结果表明，膳食维生素D可改善大鼠后外侧脊柱融合模型股骨的总体骨骼健康。这表明在围手术期对维生素D膳食摄入量进行进一步临床评估具有重要意义，有可能避免对总体骨骼健康产生不良后果。©2017骨科学研究协会。由威利期刊公司出版。《矫形外科学研究》36:1435 - 1443，2018年。
