Ziser Laura, Meyer-Schell Naja, Kurniawan Nyoman D, Sullivan Robert, Reutens David, Chen Min, Vegh Viktor
Centre for Advanced Imaging, University of Queensland, Brisbane, Qld, Australia.
Queensland Brain Institute, University of Queensland, Brisbane, Qld, Australia.
NMR Biomed. 2018 Mar;31(3). doi: 10.1002/nbm.3877. Epub 2017 Dec 20.
The availability of high-field-strength magnetic resonance imaging (MRI) systems has brought about the development of techniques that aim to map myelination via the exploitation of various contrast mechanisms. Myelin mapping techniques have the potential to provide tools for the diagnosis and treatment of diseases, such as multiple sclerosis. In this study, we evaluated the sensitivity of T *, frequency shift and susceptibility measures to myelin levels in a cuprizone mouse model of demyelination. The model was supplemented with two different dosages of fingolimod, a drug known to positively affect demyelination. A decrease in grey-white matter contrast with the cuprizone diet was observed for T *, frequency shift and susceptibility measures, together with myelin basic protein antibody findings. These results indicate that T *, frequency shift and susceptibility measures have the potential to act as biomarkers for myelination. Susceptibility was found to be the most sensitive measure to changes in grey-white matter contrast. In addition, fingolimod treatment was found to reduce the level of demyelination, with a larger dosage exhibiting a greater reduction in demyelination for the in vivo MRI results. Overall, susceptibility mapping appears to be a more promising tool than T * or frequency shift mapping for the early diagnosis and treatment of diseases in which myelination is implicated.
高场强磁共振成像（MRI）系统的出现推动了旨在通过利用各种对比机制来绘制髓鞘形成图谱的技术发展。髓鞘图谱技术有潜力为诸如多发性硬化症等疾病的诊断和治疗提供工具。在本研究中，我们在脱髓鞘的 cuprizone 小鼠模型中评估了 T *、频移和磁化率测量对髓鞘水平的敏感性。该模型补充了两种不同剂量的芬戈莫德，这是一种已知对脱髓鞘有积极影响的药物。对于 T *、频移和磁化率测量以及髓鞘碱性蛋白抗体检测结果，均观察到 cuprizone 饮食导致灰白质对比度降低。这些结果表明，T *、频移和磁化率测量有潜力作为髓鞘形成的生物标志物。发现磁化率是对灰白质对比度变化最敏感的测量指标。此外，对于体内 MRI 结果，发现芬戈莫德治疗可降低脱髓鞘水平，较大剂量表现出更大程度的脱髓鞘降低。总体而言，对于涉及髓鞘形成的疾病的早期诊断和治疗，磁化率成像似乎是比 T * 或频移成像更有前景的工具。
