温和碱促进的（杂）芳烃与苯胺的芳基化反应
Mild-Base-Promoted Arylation of (Hetero)Arenes with Anilines.
作者信息
Monzón Diego M, Santos Tanausú, Pinacho-Crisóstomo F, Martín Víctor S, Carrillo Romen
机构信息
Departamento de Química Orgánica, Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO), Universidad de La Laguna, Avda. Astrofísico Fco. Sánchez 2, Apdo. Correos 456, 38200-, La Laguna, S/C. de Tenerife, Spain.
Instituto de Productos NaturalesyAgrobiología, Consejo Superior de Investigaciones Científicas (IPNA-CSIC), Avda. Astrofísico Fco. Sánchez 3, 38206-, La Laguna, S/C. de Tenerife, Spain.
出版信息
Chem Asian J. 2018 Feb 2;13(3):325-333. doi: 10.1002/asia.201701585. Epub 2018 Jan 10.
Transition metal-free radical arylation of heteroarenes is achieved at room temperature by simply adding aqueous sodium carbonate to a solution of the corresponding heteroarene and arenediazonium salt, which can even be formed in situ. Such an easy, inexpensive and mild methodology has been optimized and applied to the expeditious modification of interesting molecular cores like naphthylimide or bisthienylcyclopentenes.
通过简单地将碳酸钠水溶液加入到相应杂芳烃和芳基重氮盐的溶液中，在室温下即可实现杂芳烃的无过渡金属自由基芳基化反应，其中芳基重氮盐甚至可以原位形成。这种简便、廉价且温和的方法已得到优化，并应用于对诸如萘二甲酰亚胺或双噻吩基环戊烯等有趣分子核心的快速修饰。
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