Bergman A, Karram M, Bhatia N N
Department of Obstetrics and Gynecology, Harbor-University of California, Los Angeles Medical Center, Torrance 90509.
J Reprod Med. 1989 Feb;34(2):157-60.
Sixty women with the diagnosis of urethral syndrome were consecutively assigned to one of three treatment modalities. The first group (20 patients) was treated with tetracycline, 2 g/d for ten days. The second group (20 patients) was treated with three serial urethral dilations at two- to three-week intervals, and the third group (20 patients) received placebo for ten days and served as a control group. A detailed clinical evaluation and uroflowmetry were performed before treatment and eight weeks afterwards. A subjective cure, which was defined as an absence of symptoms at the follow-up visits, was achieved in 20% of the placebo group, 50% of the tetracycline group and 75% of the urethral dilation group (P less than .01). An objective improvement in uroflowmetry occurred only in the group treated with serial urethral dilation.
60名被诊断为尿道综合征的女性被连续分配到三种治疗方式之一。第一组（20名患者）接受四环素治疗，每天2克，持续10天。第二组（20名患者）每隔两到三周进行三次连续尿道扩张，第三组（20名患者）接受10天的安慰剂治疗并作为对照组。在治疗前和治疗后八周进行了详细的临床评估和尿流率测定。主观治愈定义为随访时无症状，安慰剂组有20%达到主观治愈，四环素组为50%，尿道扩张组为75%（P小于0.01）。尿流率测定的客观改善仅出现在接受连续尿道扩张治疗的组中。
