猪子宫移植实验模型的描述与评估
Description and evaluation of experimental models for uterine transplantation in pigs.
作者信息
Oliveira Emerson de, Tavares Kelly Alessandra da Silva, Gomes Mariano Tamura Vieira, Salzedas-Netto Alcides Augusto, Sartori Marair Gracio Ferreira, Castro Rodrigo Aquino, Fernandes César Eduardo, Girão Manoel João Batista Castello
机构信息
Faculdade de Medicina do ABC, Santo André, SP, Brazil.
Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
出版信息
Einstein (Sao Paulo). 2017 Oct-Dec;15(4):481-485. doi: 10.1590/S1679-45082017AO4066. Epub 2017 Dec 18.
OBJECTIVE
To evaluate the technique of uterine transplantation and the use of drugs used in the process of immunosuppression.
METHODS
We included 12 sows, and immunosuppression was performed with minimal doses of cyclosporine, and cross-match was done to exclude the possibility of blood incompatibility. Hysterectomy was performed in the donor under general anesthesia, with the removal of the aorta and inferior vena cava in monobloc, and anastomosis of these vessels was made in the recipient.
RESULTS
Six experiments were performed, and on the immediate postoperative period, five animals had good reperfusion. However, on the seventh postoperative day, histological analysis showed rejection in five animals.
CONCLUSION
The experimental model of uterine transplantation is feasible, but monitoring doses of immunosuppressants is pivotal to prevent rejection episodes.
目的
评估子宫移植技术以及免疫抑制过程中所用药物的使用情况。
方法
我们纳入了12头母猪，采用最小剂量的环孢素进行免疫抑制，并进行交叉配型以排除血液不相容的可能性。在全身麻醉下对供体进行子宫切除术，整块切除主动脉和下腔静脉，并在受体中进行这些血管的吻合。
结果
进行了6次实验，术后即刻，5只动物有良好的再灌注。然而，术后第7天，组织学分析显示5只动物发生排斥反应。
结论
子宫移植的实验模型是可行的，但监测免疫抑制剂的剂量对于预防排斥反应至关重要。
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