Lu Ying-Yi, Wu Chieh-Hsin, Lu Chun-Ching, Hong Chien-Hui
Department of Dermatology, Kaohsiung Veterans General Hospital - Kaohsiung, Taiwan.
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University - Kaohsiung, Taiwan.
An Bras Dermatol. 2017;92(5 Suppl 1):92-94. doi: 10.1590/abd1806-4841.20175544.
Hyperpigmented mycosis fungoides is an extremely rare subtype of mycosis fungoides. It presents as multiple pigmented macules and patches without poikilodermatous changes and characterized by a CD8+ phenotype on immunohistochemistry. This report describes a typical case of hyperpigmented mycosis fungoides in a 62-year-old woman, who presented with a 7-year history of multiple hyperpigmented macules and patches on the trunk and right leg with progression over this half a year. Histology and immunohistochemical staining of skin samples confirmed the diagnosis of mycosis fungoides. She received psoralen plus ultraviolet A (PUVA) therapy. After an 8-week treatment, the erythematous changes cleared without recurrence during a 6-month follow-up period. An intractable hyperpigmented patch should raise the clinical suspicion of mycosis fungoides with sequential skin biopsy.
色素沉着性蕈样肉芽肿是蕈样肉芽肿一种极其罕见的亚型。它表现为多个色素沉着斑和斑片，无皮肤异色症改变，免疫组化显示为CD8 + 表型。本报告描述了一名62岁女性色素沉着性蕈样肉芽肿的典型病例，该患者躯干和右腿出现多个色素沉着斑和斑片7年，近半年病情进展。皮肤样本的组织学和免疫组化染色确诊为蕈样肉芽肿。她接受了补骨脂素加紫外线A（PUVA）治疗。经过8周治疗，红斑改变消退，在6个月的随访期内无复发。顽固性色素沉着斑应引起临床对蕈样肉芽肿的怀疑，并进行连续皮肤活检。
