四氢萘在雄性Fischer 344大鼠体内的代谢及肾毒性
Metabolism and nephrotoxicity of tetralin in male Fischer 344 rats.
作者信息
Servé M P, Llewelyn B M, Yu K O, McDonald G M, Olson C T, Hobson D W
机构信息
Department of Chemistry, Wright State University, Dayton, Ohio 45435.
出版信息
J Toxicol Environ Health. 1989;26(3):267-75. doi: 10.1080/15287398909531253.
PMID:2926829
Abstract
Tetralin, a component of fuels, solvents, and varnishes, is metabolized in male Fischer 344 rats to 1-tetralol, 2-tetralol, 2-hydroxyl-1-tetralone, 4-hydroxyl-1-tetralone, 1,2-tetralindiol, and 1,4-tetralindiol. Rats treated with tetralin demonstrated the classic lesions of hydrocarbon-induced nephropathy.
摘要
四氢化萘是燃料、溶剂和清漆的一种成分，在雄性费希尔344大鼠体内代谢生成1-四氢萘醇、2-四氢萘醇、2-羟基-1-四氢萘酮、4-羟基-1-四氢萘酮、1,2-四氢萘二醇和1,4-四氢萘二醇。用四氢化萘处理的大鼠表现出碳氢化合物诱导的肾病的典型病变。
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