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破裂性腹主动脉瘤住院治疗结局的性别差异持续存在。

Persisting disparities between sexes in outcomes of ruptured abdominal aortic aneurysm hospitalizations.

机构信息

Deerfield Institute, New York, NY, USA.

出版信息

Sci Rep. 2017 Dec 21;7(1):17994. doi: 10.1038/s41598-017-18451-2.

Abstract

We sought to describe and analyze discrepancies between sexes in the outcomes of patients hospitalized for ruptured abdominal aortic aneurysms (rAAA) by conducting a retrospective analysis of the Nationwide Inpatient Sample. The review included all adult patients (≥18 years old) hospitalized with a primary diagnosis of rAAA between January 2002 and December 2014. In-hospital mortality differences between females and males were analyzed overall and separately among those receiving endovascular AAA repair (EVAR) or open AAA repair (OAR). In-hospital mortality for females declined from 61.0% in 2002 to 49.0% in 2014 (P for trend <0.001), while mortality for males declined from 48.6% in 2002 to 32.2% in 2014 (P for trend <0.001). Among those receiving EVAR, females were significantly more likely to die in the hospital than males (adjusted odds ratio [OR], 1.44; 95% CI, 1.12-1.84). In addition, the odds of mortality among those receiving OAR were higher for females than males (adjusted OR, 1.14; 95% CI: 1.00-1.31). These data provide evidence that despite overall decreasing trends in mortality for both sexes, females remain at higher risk of death compared with males regardless of surgical repair procedure.

摘要

我们通过对全国住院患者样本进行回顾性分析,旨在描述和分析因破裂性腹主动脉瘤(rAAA)住院的患者在结局方面的性别差异。该研究纳入了 2002 年 1 月至 2014 年 12 月期间因 rAAA 被首次诊断为该病而住院的所有成年患者(≥18 岁)。我们总体分析了女性和男性患者之间的院内死亡率差异,并分别分析了接受血管内腹主动脉瘤修复术(EVAR)或开放腹主动脉瘤修复术(OAR)的患者之间的差异。女性患者的院内死亡率从 2002 年的 61.0%下降至 2014 年的 49.0%(趋势 P<0.001),而男性患者的死亡率从 2002 年的 48.6%下降至 2014 年的 32.2%(趋势 P<0.001)。在接受 EVAR 的患者中,女性患者的院内死亡率明显高于男性(校正比值比 [OR],1.44;95%置信区间,1.12-1.84)。此外,接受 OAR 的患者中女性的死亡率高于男性(校正 OR,1.14;95%置信区间:1.00-1.31)。这些数据表明,尽管两性的死亡率总体呈下降趋势,但与男性相比,女性的死亡风险仍然更高,无论采用何种手术修复方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ea3/5740124/beb5070bd2d4/41598_2017_18451_Fig1_HTML.jpg

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