Deerfield Institute, New York, NY, USA.
Sci Rep. 2017 Dec 21;7(1):17994. doi: 10.1038/s41598-017-18451-2.
We sought to describe and analyze discrepancies between sexes in the outcomes of patients hospitalized for ruptured abdominal aortic aneurysms (rAAA) by conducting a retrospective analysis of the Nationwide Inpatient Sample. The review included all adult patients (≥18 years old) hospitalized with a primary diagnosis of rAAA between January 2002 and December 2014. In-hospital mortality differences between females and males were analyzed overall and separately among those receiving endovascular AAA repair (EVAR) or open AAA repair (OAR). In-hospital mortality for females declined from 61.0% in 2002 to 49.0% in 2014 (P for trend <0.001), while mortality for males declined from 48.6% in 2002 to 32.2% in 2014 (P for trend <0.001). Among those receiving EVAR, females were significantly more likely to die in the hospital than males (adjusted odds ratio [OR], 1.44; 95% CI, 1.12-1.84). In addition, the odds of mortality among those receiving OAR were higher for females than males (adjusted OR, 1.14; 95% CI: 1.00-1.31). These data provide evidence that despite overall decreasing trends in mortality for both sexes, females remain at higher risk of death compared with males regardless of surgical repair procedure.
我们通过对全国住院患者样本进行回顾性分析,旨在描述和分析因破裂性腹主动脉瘤(rAAA)住院的患者在结局方面的性别差异。该研究纳入了 2002 年 1 月至 2014 年 12 月期间因 rAAA 被首次诊断为该病而住院的所有成年患者(≥18 岁)。我们总体分析了女性和男性患者之间的院内死亡率差异,并分别分析了接受血管内腹主动脉瘤修复术(EVAR)或开放腹主动脉瘤修复术(OAR)的患者之间的差异。女性患者的院内死亡率从 2002 年的 61.0%下降至 2014 年的 49.0%(趋势 P<0.001),而男性患者的死亡率从 2002 年的 48.6%下降至 2014 年的 32.2%(趋势 P<0.001)。在接受 EVAR 的患者中,女性患者的院内死亡率明显高于男性(校正比值比 [OR],1.44;95%置信区间,1.12-1.84)。此外,接受 OAR 的患者中女性的死亡率高于男性(校正 OR,1.14;95%置信区间:1.00-1.31)。这些数据表明,尽管两性的死亡率总体呈下降趋势,但与男性相比,女性的死亡风险仍然更高,无论采用何种手术修复方式。