踝臂指数和臂踝脉搏波速度与原发性高血压患者心脏结构和功能的相关性分析。
Correlation analysis of ankle-brachial index and brachial-ankle pulse wave velocity with cardiac structures and functions in patients with essential hypertension.
机构信息
Nursing Department, People's Hospital of Rizhao, Rizhao, China.
出版信息
Eur Rev Med Pharmacol Sci. 2017 Dec;21(24):5798-5804. doi: 10.26355/eurrev_201712_14027.
OBJECTIVE
To investigate the correlation of ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) with cardiac structures and functions changes in patients with essential hypertension (EH).
PATIENTS AND METHODS
A total of 202 patients with hypertension meeting the inclusion criteria were recruited in our hospital from June 2016 to August 2017. They were divided into 4 groups: the low ABI value group, the normal ABI value group, the increased baPWV value group and the normal baPWV group. Clinical data were collected, including medical histories and received physical examinations, blood pressure measurement, biochemical tests and other examinations through the automatic atherosclerosis tester (VP-l00) and echocardiography.
RESULTS
Interventricular septal thickness (IVST) of the low ABI value group was significantly larger than that of the normal ABI value group (p<0.05). Compared with those of the normal ABI value group, left ventricular ejection fraction (LVEF) and the ratio of peak velocity flow in the E wave to peak velocity flow in the A wave (E/A) of the low ABI value group were significantly decreased (p<0.05). Left atrium diameter (LAD) and IVST of the increased baPWV group were significantly greater than those of the normal baPWV group (p<0.05), and left ventricular ejection fraction (LVEF) of the former was smaller than that of the latter (p<0.05). Correlation analyses showed that ABI was negatively correlated with IVST (r=-0.713, p<0.05) but positively correlated with LVEF and E/A (r=0.685 and 0.572, respectively, p<0.05); baPWV was positively related to LAD and LVST (r=0.413 and 0.527, respectively, p<0.05) but negatively related to LVEF (r=-0.546, p<0.05).
CONCLUSIONS
ABI and baPWV are significantly associated with changes in cardiac structures and functions in patients with EH, which provide a basis for early intervention in clinical.
目的
探讨踝臂指数（ABI）和臂踝脉搏波速度（baPWV）与原发性高血压（EH）患者心脏结构和功能变化的相关性。
患者与方法
本研究共纳入 202 名符合纳入标准的高血压患者，他们均于 2016 年 6 月至 2017 年 8 月在我院接受治疗。将这些患者分为 4 组：低 ABI 值组、正常 ABI 值组、高 baPWV 值组和正常 baPWV 组。收集临床数据，包括病史和体格检查、血压测量、生化检查以及通过自动动脉硬化测试仪（VP-100）和超声心动图进行的其他检查。
结果
低 ABI 值组的室间隔厚度（IVST）明显大于正常 ABI 值组（p<0.05）。与正常 ABI 值组相比，低 ABI 值组的左心室射血分数（LVEF）和 E 波峰值流速与 A 波峰值流速的比值（E/A）明显降低（p<0.05）。高 baPWV 组的左心房直径（LAD）和 IVST 明显大于正常 baPWV 组（p<0.05），而前者的左心室射血分数（LVEF）小于后者（p<0.05）。相关性分析表明，ABI 与 IVST 呈负相关（r=-0.713，p<0.05），与 LVEF 和 E/A 呈正相关（r=0.685 和 0.572，分别，p<0.05）；baPWV 与 LAD 和 LVST 呈正相关（r=0.413 和 0.527，分别，p<0.05），与 LVEF 呈负相关（r=-0.546，p<0.05）。
结论
ABI 和 baPWV 与 EH 患者心脏结构和功能变化显著相关，为临床早期干预提供了依据。
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