Hilakivi L A, Durcan M J, Lister R G
Laboratory of Clinical Studies, National Institute on Alcohol Abuse & Alcoholism, Bethesda, MD 20892.
Life Sci. 1989;44(8):543-53. doi: 10.1016/0024-3205(89)90616-4.
The effects of caffeine and its interaction with ethanol were examined in a test of social behavior and a holeboard test of exploration and locomotion. Male mice were injected i.p. with 15, 30 or 60 mg/kg caffeine alone or in combination with 2 g/kg ethanol. The animals were then put in pairs into a familiar arena, or examined individually in the holeboard. Only the highest dose of caffeine (60 mg/kg) had a significant effect on the time spent in social interaction and motor activity in the social behavior test: both measures were reduced. The duration and frequency of avoidance-irritability behavior was dose-dependently increased by caffeine. In the holeboard, caffeine caused a dose-dependent increase in locomotor activity. 30 mg/kg caffeine reversed the ethanol-induced reduction of time spent in social interaction, and 60 mg/kg caffeine antagonized the ethanol-induced increase in locomotor activity in both the social behavior and holeboard tests. Caffeine's effects on ethanol-induced behavioral changes are compared with those of other drugs.
在一项社会行为测试以及一项探索与运动的洞板试验中，研究了咖啡因的作用及其与乙醇的相互作用。给雄性小鼠腹腔注射15、30或60毫克/千克的咖啡因，单独注射或与2克/千克乙醇联合注射。然后将动物成对放入一个熟悉的场地，或者在洞板中单独进行检查。在社会行为测试中，只有最高剂量的咖啡因（60毫克/千克）对社交互动时间和运动活动有显著影响：这两项指标均降低。咖啡因使回避-易怒行为的持续时间和频率呈剂量依赖性增加。在洞板试验中，咖啡因使运动活动呈剂量依赖性增加。在社会行为和洞板试验中，30毫克/千克的咖啡因逆转了乙醇诱导的社交互动时间减少，60毫克/千克的咖啡因拮抗了乙醇诱导的运动活动增加。将咖啡因对乙醇诱导的行为变化的影响与其他药物的影响进行了比较。
