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Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases.重建的祖先酶表明，负选择推动了ADP依赖性激酶底物特异性的进化。
J Biol Chem. 2017 Dec 22;292(51):21218. doi: 10.1074/jbc.AAC117.001147.
2
Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases.重建的祖先酶表明，负选择驱动了ADP依赖性激酶底物特异性的进化。
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引用本文的文献

1
Structure of an ancestral ADP-dependent kinase with fructose-6P reveals key residues for binding, catalysis, and ligand-induced conformational changes.具有果糖-6-P 的古老 ADP 依赖性激酶的结构揭示了结合、催化和配体诱导的构象变化的关键残基。
J Biol Chem. 2021 Jan-Jun;296:100219. doi: 10.1074/jbc.RA120.015376. Epub 2020 Dec 24.
2
Beta class amino methyltransferases from bacteria to humans: evolution and structural consequences.β 级氨基甲基转移酶：从细菌到人——进化与结构后果。
Nucleic Acids Res. 2020 Oct 9;48(18):10034-10044. doi: 10.1093/nar/gkaa446.

Reconstructed ancestral enzymes reveal that negative selection drove the evolution of substrate specificity in ADP-dependent kinases.

作者信息

Castro-Fernandez Víctor, Herrera-Morande Alejandra, Zamora Ricardo, Merino Felipe, Gonzalez-Ordenes Felipe, Padilla-Salinas Felipe, Pereira Humberto M, Brandão-Neto Jose, Garratt Richard C, Guixe Victoria

出版信息

J Biol Chem. 2017 Dec 22;292(51):21218. doi: 10.1074/jbc.AAC117.001147.

DOI:10.1074/jbc.AAC117.001147
PMID:29273585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5743094/
Abstract
摘要