N-甲基腺嘌呤是哺乳动物早期生活应激的表观遗传标记。
N-methyladenine is an epigenetic marker of mammalian early life stress.
机构信息
Molecular and Cellular Pharmacology Training Program, University of Wisconsin-Madison, Madison, WI, 53706, United States.
Department of Psychology, University of Wisconsin-Madison, University of Wisconsin-Madison, Madison, WI, 53706, United States.
出版信息
Sci Rep. 2017 Dec 22;7(1):18078. doi: 10.1038/s41598-017-18414-7.
Recent evidence described 6-methyladenine (6 mA) as a novel epigenetic regulator in a variety of multicellular species, including rodents; however, its capacity to influence gene expression in the mammalian brain remains unknown. We examined if 6 mA is present and regulated by early life stress associated with predator odor exposure (POE) within the developing rat amygdala. Our results provide evidence that 6 mA is present in the mammalian brain, is altered within the Htr2a gene promoter by early life stress and biological sex, and increased 6 mA is associated with gene repression. These data suggest that methylation of adenosine within mammalian DNA may be used as an additional epigenetic biomarker for investigating the development of stress-induced neuropathology.
最近的证据表明，6-甲基腺嘌呤（6mA）在包括啮齿动物在内的多种多细胞生物中是一种新型的表观遗传调节剂；然而，其在哺乳动物大脑中影响基因表达的能力尚不清楚。我们研究了 6mA 是否存在，并受与捕食者气味暴露（POE）相关的早期生活应激调节，这种应激存在于发育中的大鼠杏仁核内。我们的结果提供了证据，表明 6mA 存在于哺乳动物的大脑中，它在 Htr2a 基因启动子中通过早期生活应激和生物性别而改变，并且增加的 6mA 与基因抑制有关。这些数据表明，哺乳动物 DNA 中腺苷的甲基化可用作研究应激诱导的神经病理学发展的另一种表观遗传生物标志物。
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