University of Illinois at Urbana-Champaign, Beckman Institute for Advanced Science and Technology, U, United States.
University of Illinois at Urbana-Champaign, Department of Electrical and Computer Engineering, Urban, United States.
J Biomed Opt. 2017 Dec;22(12):1-23. doi: 10.1117/1.JBO.22.12.121711.
The application of optical coherence tomography (OCT) in the field of oncology has been prospering over the past decade. OCT imaging has been used to image a broad spectrum of malignancies, including those arising in the breast, brain, bladder, the gastrointestinal, respiratory, and reproductive tracts, the skin, and oral cavity, among others. OCT imaging has initially been applied for guiding biopsies, for intraoperatively evaluating tumor margins and lymph nodes, and for the early detection of small lesions that would often not be visible on gross examination, tasks that align well with the clinical emphasis on early detection and intervention. Recently, OCT imaging has been explored for imaging tumor cells and their dynamics, and for the monitoring of tumor responses to treatments. This paper reviews the evolution of OCT technologies for the clinical application of OCT in surgical and noninvasive interventional oncology procedures and concludes with a discussion of the future directions for OCT technologies, with particular emphasis on their applications in oncology.
在过去的十年中，光学相干断层扫描（OCT）在肿瘤学领域的应用蓬勃发展。OCT 成像已被用于成像广泛的恶性肿瘤，包括乳腺、脑、膀胱、胃肠道、呼吸道和生殖系统、皮肤和口腔等部位的肿瘤。OCT 成像最初被用于引导活检，术中评估肿瘤边缘和淋巴结，以及早期检测通常在大体检查中不可见的小病变，这些任务与临床强调早期检测和干预的目标非常一致。最近，OCT 成像已被用于成像肿瘤细胞及其动力学，以及监测肿瘤对治疗的反应。本文回顾了 OCT 技术在手术和非侵入性介入性肿瘤学程序中的临床应用的发展，并讨论了 OCT 技术的未来发展方向，特别强调了它们在肿瘤学中的应用。
