Mendez M F, Adams N L, Lewandowski K S
Case Western Reserve University, Cleveland, OH.
Neurology. 1989 Mar;39(3):349-54. doi: 10.1212/wnl.39.3.349.
We report behavioral and cognitive characteristics of 12 patients with caudate nuclei lesions, 11 unilateral and one bilateral. These patients developed an acute behavioral change characterized by apathy, disinhibition, or a major affective disturbance. The pattern of personality change correlated with size and location of lesion within the caudate but not the laterality. Seven patients were further compared with matched controls on a series of neuropsychological tests. Their performance was impaired on tasks requiring planning and sequencing. They had short attention spans and decreased free recall of episodic and semantic items with good recognition memory scores. Similar behavioral and cognitive changes also occur in early Huntington's disease, frontal-lesioned patients, and caudate-lesioned animals, and correspond to disturbances of specific frontal-caudate circuits. These results implicate the caudate nuclei in mediating prefrontal behaviors and possibly in the conceptual integration of memories.
我们报告了12例尾状核病变患者的行为和认知特征，其中11例为单侧病变，1例为双侧病变。这些患者出现了以冷漠、去抑制或严重情感障碍为特征的急性行为改变。人格改变模式与尾状核内病变的大小和位置相关，而非与病变的侧别相关。7例患者在一系列神经心理学测试中与匹配的对照组进行了进一步比较。他们在需要计划和排序的任务上表现受损。他们的注意力持续时间较短，情节性和语义性项目的自由回忆减少，但识别记忆分数良好。类似的行为和认知变化也发生在早期亨廷顿病、额叶病变患者和尾状核病变动物中，并且与特定额叶 - 尾状核回路的紊乱相对应。这些结果表明尾状核在介导前额叶行为以及可能在记忆的概念整合中起作用。
