非小细胞肺癌脑转移中PD-L1表达的临床意义
Clinical Significance of PD-L1 Expression in Brain Metastases from Non-small Cell Lung Cancer.
作者信息
Takamori Shinkichi, Toyokawa Gouji, Okamoto Isamu, Takada Kazuki, Kinoshita Fumihiko, Kozuma Yuka, Matsubara Taichi, Haratake Naoki, Akamine Takaki, Mukae Nobutaka, Hirai Fumihiko, Tagawa Tetsuzo, Oda Yoshinao, Iwaki Toru, Iihara Koji, Nakanishi Yoichi, Maehara Yoshihiko
机构信息
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Higashi, Fukuoka, Japan.
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Higashi, Fukuoka, Japan
出版信息
Anticancer Res. 2018 Jan;38(1):553-557. doi: 10.21873/anticanres.12258.
AIM
To investigate the association between positivity for programmed cell death-ligand 1 (PD-L1) in brain metastases (BM) and the prognosis or clinical factors in patients with non-small cell lung cancer (NSCLC).
MATERIALS AND METHODS
Thirty-two patients with surgically resected brain-metastatic NSCLC were enrolled. The PD-L1 expression in BM was analyzed using the antibody against human PD-L1 (clone SP142). The PD-L1 positivity was defined as PD-L1 expression on brain-metastatic tumor cells of ≥5%.
RESULTS
Seven (21.9%) out of 32 patients showed PD-L1 positivity in BM. The PD-L1-positive BM group had a significantly shorter brain-specific disease-free survival than the PD-L1-negative BM group (p<0.05). PD-L1 positivity in BM was significantly associated with a heavy smoking history and the administration of radiotherapy for BM before surgery (p<0.05 and p<0.05, respectively).
CONCLUSION
The PD-L1 expression in BM from NSCLC may be associated with local recurrence following surgery, and the smoking- or radiotherapy-derived effects.
目的
探讨脑转移（BM）中程序性细胞死亡配体1（PD-L1）阳性与非小细胞肺癌（NSCLC）患者预后及临床因素之间的关联。
材料与方法
纳入32例接受手术切除的脑转移NSCLC患者。使用抗人PD-L1抗体（克隆号SP142）分析BM中PD-L1的表达。PD-L1阳性定义为脑转移肿瘤细胞上PD-L1表达≥5%。
结果
32例患者中有7例（21.9%）BM显示PD-L1阳性。PD-L1阳性BM组的脑特异性无病生存期明显短于PD-L1阴性BM组（p<0.05）。BM中PD-L1阳性与大量吸烟史及术前对BM进行放疗显著相关（分别为p<0.05和p<0.05）。
结论
NSCLC患者BM中PD-L1表达可能与术后局部复发以及吸烟或放疗的影响有关。
Zotero 插件