Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan; Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Department of Radiology, National Center of Neurology and Psychiatry, Tokyo, Japan.
Parkinsonism Relat Disord. 2018 Mar;48:10-16. doi: 10.1016/j.parkreldis.2017.12.021. Epub 2017 Dec 21.
In Parkinson's disease (PD) patients, magnetic resonance (MR) imaging studies using phase difference enhanced imaging (PADRE) and susceptibility-weighted imaging (SWI) showed the obscuration of the boundary between the crural fibers and substantia nigra, and the absence of dorsolateral nigral hyperintensity, respectively. PADRE images have not been evaluated in other types of neurodegenerative parkinsonism, and PADRE and SWI images have not been compared. Here we evaluated PADRE and SWI images in patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA), or PD and controls, and we compared the diagnostic values.
PADRE and SWI-like MR images were visually assessed focusing on the substantia nigra in 39 PD patients, eight with PSP, 13 with MSA, and 34 normal controls.
The obscuration of the boundary between the crural fibers and substantia nigra on PADRE was observed in: the PD group, 62%; PSP, 100%; MSA, 60%, and controls, 19%. The overall collect classification for neurodegenerative parkinsonism was 74%. The absence of dorsolateral nigral hyperintensity on SWI-like images was present in: PD, 97%; PSP, 100%; MSA, 67%; and controls, 6%, resulting in the overall correct classification of 96%.
The MR feature on PADRE was observed not only in PD but also in other neurodegenerative parkinsonism, especially in PSP with high sensitivity. The finding in substantia nigra on SWI had greater discrimination power than that of PADRE in neurodegenerative parkinsonism, especially in PD.
在帕金森病（PD）患者中，磁共振（MR）成像研究使用相位对比增强成像（PADRE）和磁敏感加权成像（SWI）分别显示了内囊纤维和黑质之间边界的模糊以及背外侧黑质高信号的缺失。尚未在其他类型的神经退行性帕金森病中评估 PADRE 图像，也尚未比较 PADRE 和 SWI 图像。在这里，我们评估了进展性核上性麻痹（PSP）、多系统萎缩（MSA）或 PD 患者和对照组的 PADRE 和 SWI 图像，并比较了其诊断价值。
在 39 名 PD 患者、8 名 PSP 患者、13 名 MSA 患者和 34 名正常对照者中，我们通过视觉评估 PADRE 和类似 SWI 的 MR 图像，重点关注黑质。
在 PADRE 上观察到内囊纤维和黑质之间边界的模糊：PD 组，62%；PSP，100%；MSA，60%，对照组，19%。神经退行性帕金森病的整体集合分类为 74%。SWI 类似图像上背外侧黑质高信号的缺失存在于：PD，97%；PSP，100%；MSA，67%；对照组，6%，导致整体正确分类为 96%。
PADRE 的 MR 特征不仅在 PD 中观察到，而且在其他神经退行性帕金森病中也观察到，尤其是在 PSP 中具有高灵敏度。SWI 上黑质的发现比 PADRE 在神经退行性帕金森病中具有更高的辨别力，尤其是在 PD 中。
