阿托伐他汀对急性脊髓损伤患者的影响。
Effects of Atorvastatin in Patients with Acute Spinal Cord Injury.
作者信息
Aghazadeh Javad, Samadi Motlagh Parviz, Salehpour Firooz, Meshkini Ali, Fatehi Majid, Mirzaei Farhad, Naseri Alavi Seyed Ahmad
机构信息
Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Asian Spine J. 2017 Dec;11(6):903-907. doi: 10.4184/asj.2017.11.6.903. Epub 2017 Dec 7.
STUDY DESIGN
Clinical trial study.
PURPOSE
The aim of this study was to evaluate the effect of atorvastatin on sensory and motor function in patients with acute spinal cord injury.
OVERVIEW OF LITERATURE
The prevalence and incidence of traumatic spinal cord injury are increasing. Statins are well established for use in hypercholesterolemia as well as during anti-inflammatory events.
METHODS
This clinical trial study included 60 patients with acute spinal cord injury. These were randomly divided into two groups: the case group which received atorvastatin and also underwent surgical therapy and the control group which only underwent surgical therapy.
RESULTS
The severity of spinal cord lesions was evaluated based on the Frankel grade at three periods; this showed no significant difference between the two groups. Comparisons of the levels of pain between the groups based on a Visual Analog Scale system showed no significant difference at the three periods.
CONCLUSIONS
We observed no improvement at the 3- and 6-month follow-up in patients who were administered atorvastatin. However, a comparison of the two groups based on pain severity demonstrated a significant difference, suggesting that atorvastatin had a positive effect on patients with spinal cord injury.
研究设计
临床试验研究。
目的
本研究旨在评估阿托伐他汀对急性脊髓损伤患者感觉和运动功能的影响。
文献综述
创伤性脊髓损伤的患病率和发病率正在上升。他汀类药物在高胆固醇血症以及抗炎过程中的应用已得到充分证实。
方法
本临床试验研究纳入60例急性脊髓损伤患者。这些患者被随机分为两组：接受阿托伐他汀治疗并接受手术治疗的病例组和仅接受手术治疗的对照组。
结果
在三个时期根据Frankel分级评估脊髓损伤的严重程度；两组之间无显著差异。基于视觉模拟量表系统对两组之间疼痛程度的比较在三个时期均无显著差异。
结论
我们观察到接受阿托伐他汀治疗的患者在3个月和6个月随访时没有改善。然而，基于疼痛严重程度对两组进行比较显示出显著差异，表明阿托伐他汀对脊髓损伤患者有积极作用。
Zotero 插件