Ballestero Matheus Fernando Manzolli, Viana Dinark Conceição, Teixeira Thiago Lyrio, Santos Marcelo Volpon, de Oliveira Ricardo Santos
Division of Pediatric Neurosurgery of the Department of Surgery and Anatomy, University Hospital of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, 14049-900, Brazil.
Childs Nerv Syst. 2018 Mar;34(3):409-415. doi: 10.1007/s00381-017-3705-6. Epub 2017 Dec 26.
Hypertrophic olivary degeneration (HOD) is a rare transsynaptic form of degeneration occurring after injury to the dentato-rubro-olivary pathway ("Guillain-Mollaret triangle"). The majority of studies have described HOD resulting from posterior fossa (PF) hemorrhage or infarction. HOD in patients undergoing PF surgery has not been well characterized. These lesions are rare and symptomatic children with HOD are even more uncommon. The purpose of this study was to evaluate HOD that develops after PF operations in children.
A literature review was carried out describing 37 pediatric cases of HOD in 13 articles. In addition, two new cases of our own experience were included.
HOD is a rare complication related after PF tumors surgery and symptoms may be misdiagnosed with pediatric cerebellar mutism syndrome. Children with HOD usually do not develop palatal tremor but ataxia is common.
肥大性橄榄核变性（HOD）是一种罕见的跨突触变性形式，发生于齿状核-红核-橄榄核通路（“ Guillain-Mollaret三角”）损伤后。大多数研究描述了后颅窝（PF）出血或梗死导致的HOD。PF手术患者中的HOD尚未得到充分描述。这些病变罕见，有症状的HOD患儿更为少见。本研究的目的是评估儿童PF手术后发生的HOD。
进行文献综述，描述13篇文章中的37例儿科HOD病例。此外，纳入了我们自己经验中的2例新病例。
HOD是PF肿瘤手术后罕见的并发症，症状可能被误诊为小儿小脑缄默综合征。HOD患儿通常不会出现腭震颤，但共济失调很常见。
