病毒诱导的红细胞白血病自然恢复后，感染性弗氏病毒在小鼠脾脏中的持续存在。
Persistence of infectious Friend virus in spleens of mice after spontaneous recovery from virus-induced erythroleukemia.
作者信息
Chesebro B, Bloom M, Wehrly K, Nishio J
出版信息
J Virol. 1979 Dec;32(3):832-7. doi: 10.1128/JVI.32.3.832-837.1979.
Abstract
Persistent infectious virus was detected in the majority of spleens of (C57BL/10 X A.BY)F1 mice after spontaneous recovery from Friend virus-induced erythroleukeima. The Friend murine leukemia helper virus (F-MuLV) was detected in titers up to 3 X 10(5) PFU/g of spleen. The defective spleen focus-forming virus (SFFV) was present in much lower titers and could be detected in cell-free spleen homogenates only after amplification of virus titer by growth of virus in vitro on SC1 cells. The incidence of cells producing F-MuLV alone in spleens after recovery from leukemia was 0.003 to 0.3%, and the incidence of cells producing both F-MuLV and SFFV was less than 0.0001 to 0.01%. In most recovered mouse spleens there appeared to be a selective reduction of SFFV relative to F-MuLV.
摘要
在（C57BL/10×A.BY）F1小鼠从弗瑞德病毒诱导的红白血病自然恢复后，在大多数脾脏中检测到持续感染的病毒。在脾脏中检测到的弗瑞德鼠白血病辅助病毒（F-MuLV）滴度高达3×10⁵PFU/g。缺陷型脾脏集落形成病毒（SFFV）的滴度要低得多，只有在病毒在SC1细胞上体外生长使病毒滴度扩增后，才能在无细胞脾脏匀浆中检测到。白血病恢复后，脾脏中仅产生F-MuLV的细胞发生率为0.003%至0.3%，同时产生F-MuLV和SFFV的细胞发生率小于0.0001%至0.01%。在大多数恢复的小鼠脾脏中，相对于F-MuLV，SFFV似乎有选择性减少。
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