Reyes-Capó Daniela, Cavuoto Kara M, Chang Ta C
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.
Asia Pac J Ophthalmol (Phila). 2018 Mar-Apr;7(2):95-98. doi: 10.22608/APO.2017447. Epub 2017 Dec 27.
The incidence of infantile-onset secondary glaucoma associated with periocular cutaneous vascular malformations is high and the outcomes of these glaucomatous eyes have anecdotally been poor. The purpose of this study was to determine the anatomic and visual outcomes of affected eyes.
Retrospective case series.
Consecutive patients with early-onset (younger than 36 months of age) glaucoma associated with cutaneous vascular malformations from 1995‒2015 were included.
Seventeen eyes of 13 patients with Sturge-Weber syndrome (SW, n = 10), Klippel-Trenaunay-Weber syndrome (KTW, n = 1), cutis marmorata telangiectatica congenita (CMTC, n = 1), and phakomatosis pigmentovascularis (PPV, n = 1) were included. Three SW and 1 KTW patient had bilateral glaucoma. At presentation, mean age was 6.5 ± 9.1 months and mean intraocular pressure was 27.2 ± 6.13 mm Hg. The average number of surgical procedures per eye increased from 1.0 ± 0.5 (range, 0‒2) at less than 5 years' follow-up (9 eyes) to 3.5 ± 2.3 (range, 1‒7) with at least 5 years' follow-up (8 eyes). Visual acuity was better than or equal to 20/70 in 2 of 6 eyes (33%) with less than 5 years' follow-up and in 3 of 7 eyes (43%) with at least 5 years' follow-up. Additionally, a higher number of baseline risk factors correlated with poorer visual outcome.
After a mean follow-up of 6.6 years, visual outcome in infantile-onset secondary glaucoma associated with cutaneous periocular vascular malformation is guarded. Increased numbers of baseline risk factors and procedures are associated with poorer vision.
与眼周皮肤血管畸形相关的婴儿期继发性青光眼发病率较高，据传闻这些青光眼患眼的预后较差。本研究的目的是确定患眼的解剖学和视觉预后。
回顾性病例系列研究。
纳入1995年至2015年期间患有与皮肤血管畸形相关的早发性（年龄小于36个月）青光眼的连续患者。
纳入了13例患者的17只眼，其中患有斯特奇-韦伯综合征（SW，n = 10）、克-特-韦综合征（KTW，n = 1）、先天性大理石样皮肤毛细血管扩张症（CMTC，n = 1）和色素血管性母斑病（PPV，n = 1）。3例SW患者和1例KTW患者患有双侧青光眼。就诊时，平均年龄为6.5±9.1个月，平均眼压为27.2±6.13 mmHg。随访时间少于5年（9只眼）时，每只眼的平均手术次数为1.0±0.5（范围0至2），随访时间至少5年（八只眼）时，平均手术次数为3.5±2.3（范围1至7）。随访时间少于5年的6只眼中有2只（33%）视力优于或等于20/70，随访时间至少5年的7只眼中有3只（43%）视力优于或等于20/70。此外，更多的基线危险因素与较差的视觉预后相关。
平均随访6.6年后，与眼周皮肤血管畸形相关的婴儿期继发性青光眼的视觉预后不容乐观。基线危险因素数量增加和手术次数增多与视力较差相关。
