Department of Biological Psychiatry, Medical University of Lodz, Lodz, Poland.
Psychiatry Clin Neurosci. 2018 May;72(5):329-336. doi: 10.1111/pcn.12631. Epub 2018 Feb 8.
The aim of the present study was to evaluate and compare the effects of a new antipsychotic, aripiprazole (unique due to its mechanism of action), with the effects of selected antipsychotic drugs, such as quetiapine, olanzapine, clozapine, risperidone, and ziprasidone (at the final concentrations corresponding to clinically effective doses used for the treatment of acute episodes of schizophrenia) on lipid peroxidation in human plasma measured by the level of thiobarbituric acid reactive substances (TBARS), which is a marker of oxidative stress.
The levels of TBARS were measured spectrophotometrically, according to the modification of the Rice-Evans method.
Our results indicate that antipsychotics at doses recommended for the treatment of acute episodes of schizophrenia may induce distinct changes in the levels of lipid peroxidation products (TBARS) in plasma. Aripiprazole had no effect on the level of a lipid peroxidation marker in plasma, although used at lower doses it showed insignificant prooxidative properties similar to clozapine. Quetiapine had the strongest antioxidant properties, contrary to prooxidative action of risperidone, ziprasidone or haloperidol, and clozapine at lower doses. Olanzapine reduced the level of TBARS in plasma only at a lower dose.
Antipsychotics at doses recommended for the treatment of acute episode in schizophrenia may induce the distinct changes in plasma lipid peroxidation. Aripiprazole did not induce significant changes in plasma lipid peroxidation. In further studies, the role of oxidative stress in schizophrenic patients together with their clinical symptomatology and use of antipsychotics should be taken into account.
本研究旨在评估和比较新型抗精神病药阿立哌唑（因其作用机制而独特）与其他几种抗精神病药物（如喹硫平、奥氮平、氯氮平、利培酮和齐拉西酮）的效果，这些药物的终浓度对应于用于治疗精神分裂症急性发作的临床有效剂量，以测定人血浆中脂质过氧化产物（TBARS）的水平，TBARS 是氧化应激的标志物。
采用 Rice-Evans 法的改良法，分光光度法测定 TBARS 水平。
我们的结果表明，用于治疗精神分裂症急性发作的推荐剂量的抗精神病药可能会导致血浆中脂质过氧化产物（TBARS）水平的明显变化。阿立哌唑对血浆中脂质过氧化标志物的水平没有影响，尽管它的使用剂量较低，但具有类似于氯氮平的轻微促氧化特性。喹硫平具有最强的抗氧化特性，与利培酮、齐拉西酮或氟哌啶醇的促氧化作用相反，而氯氮平在较低剂量下也具有促氧化作用。奥氮平仅在较低剂量下降低血浆 TBARS 水平。
用于治疗精神分裂症急性发作的推荐剂量的抗精神病药可能会引起血浆脂质过氧化的明显变化。阿立哌唑未引起血浆脂质过氧化的显著变化。在进一步的研究中，应考虑氧化应激在精神分裂症患者中的作用及其临床症状和抗精神病药的使用。
