Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University , Chengdu 610064, P. R. China.
College of Chemistry and Chemical Engineering, Neijiang Normal University , Neijiang 641112, P. R. China.
Org Lett. 2018 Jan 5;20(1):190-193. doi: 10.1021/acs.orglett.7b03551. Epub 2017 Dec 27.
A selective oxy-difluoroalkylation of allylamines with carbon dioxide (CO) via visible-light photoredox catalysis is reported. These multicomponent reactions are efficient and environmentally friendly to generate a series of important 2-oxazolidinones with functionalized difluoroalkyl groups. The good functional group tolerance, broad substrate scope, easy scalability, mild reaction conditions, and facile functionalization of products provide great potential for application in organic synthesis and pharmaceutical chemistry.
本文报道了通过可见光光氧化还原催化，二氧化碳（CO）与烯丙胺的选择性氧-二氟烷基化反应。这些多组分反应高效且环保，可生成一系列具有官能化二氟烷基的重要 2-噁唑烷酮。良好的官能团耐受性、广泛的底物范围、易于扩大规模、温和的反应条件以及产物的易功能化，为其在有机合成和药物化学中的应用提供了巨大的潜力。
