Sánchez Torralvo Francisco José, Valdés Hernández Sergio, Tapia María José, Abuín Fernández José, Olveira Gabriel
UGC Endocrinología y Nutrición. Hospital Regional Universitario de Málaga. Universidad de Málaga..
Nutr Hosp. 2017 Nov 16;34(5):1482-1488. doi: 10.20960/nh.1220.
Obesity is a prevalent disease in our environment, which comorbidities suppose a great challenge to public health. Intragastric injection of botulinum toxin has been used as treatment for obesity, both in humans and animals. It acts by inhibiting gastric emptying and inducing early satiety, consequently reducing intake and finally achieving weight loss.
A bibliographic search in PubMed, Scopus and EMBASE databases between 2000 and 2016 was carried out. Articles regarding the physiological basis of the treatment with intragastric injection of botulinum toxin in human were included, as well as interventional studies, randomised or not.
A total of 105 articles were found and 10 were chosen according to our inclusion criteria. Of those, only 4 were randomised and 8 lasted between 8 and 24 weeks. In four of the studies, one randomised, a statistically significant weight loss was found which varied between 3.5 and 11.8 kg. Most of the studies found slowing of gastric emptying. None of them notified any significant side-effects.
Intragastric injection of botulinum toxin could be useful and safe in the treatment of obesity but better designed, placebo-controlled, long term and with an adequate sample size studies are needed.
肥胖在我们所处的环境中是一种普遍存在的疾病，其合并症对公共卫生构成了巨大挑战。胃内注射肉毒杆菌毒素已被用于人类和动物的肥胖治疗。它通过抑制胃排空和诱导早期饱腹感起作用，从而减少摄入量并最终实现体重减轻。
在2000年至2016年期间对PubMed、Scopus和EMBASE数据库进行了文献检索。纳入了关于胃内注射肉毒杆菌毒素治疗人类的生理基础的文章，以及干预性研究，无论是否为随机研究。
共找到105篇文章，根据纳入标准选择了10篇。其中，只有4篇是随机研究，8篇持续时间在8至24周之间。在四项研究中，一项为随机研究，发现体重有统计学意义的减轻，减轻幅度在3.5至11.8千克之间。大多数研究发现胃排空减慢。它们均未报告任何显著的副作用。
胃内注射肉毒杆菌毒素在肥胖治疗中可能是有用且安全的，但需要设计更好、有安慰剂对照、长期且样本量充足的研究。
