Huang Yu-Jui, Tsai Shang-Ying, Chung Kuo-Hsuan, Chen Pao-Huan, Huang Shou-Hung, Kuo Chian-Jue
1 Department of Psychiatry and Psychiatric Research Center, Taipei Medical University Hospital, Taipei, Taiwan.
2 Department of Psychiatry, Taipei Medical University Hospital, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Int J Psychiatry Med. 2018 Jul;53(4):273-281. doi: 10.1177/0091217417749786. Epub 2017 Dec 27.
Objective Serum lipid levels may be associated with the affective severity of bipolar disorder, but data on lipid profiles in Asian patients with bipolar disorder and the lipid alterations in different states of opposite polarities are scant. We investigated the lipid profiles of patients in the acute affective, partial, and full remission state in bipolar mania and depression. Methods The physically healthy patients aged between 18 and 45 years with bipolar I disorder, as well as age-matched healthy normal controls were enrolled. We compared the fasting blood levels of glucose, cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein of manic or depressed patients in the acute phase and subsequent partial and full remission with those of their normal controls. Results A total of 32 bipolar manic patients (12 women and 20 men), 32 bipolar depressed participants (18 women and 14 men), and 64 healthy control participants took part in this study. The mean cholesterol level in acute mania was significantly lower than that in acute depression (p < 0.025). The lowest rate of dyslipidemia (hypertriglyceridemia or low high-density lipoprotein cholesterol) was observed in acute bipolar mania. Conclusion Circulating lipid profiles may be easily affected by affective states. The acute manic state may be accompanied by state-dependent lower cholesterol and triglyceride levels relative to that in other mood states.
目的 血清脂质水平可能与双相情感障碍的情感严重程度相关，但关于亚洲双相情感障碍患者的血脂谱以及不同极性相反状态下的脂质变化的数据很少。我们研究了双相躁狂和抑郁患者在急性情感期、部分缓解期和完全缓解期的血脂谱。方法 纳入年龄在18至45岁之间的患有双相I型障碍的身体健康患者以及年龄匹配的健康正常对照。我们比较了躁狂或抑郁患者急性期及随后部分缓解期和完全缓解期的空腹血糖、胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白水平与正常对照的水平。结果 共有32名双相躁狂患者（12名女性和20名男性）、32名双相抑郁参与者（18名女性和14名男性）以及64名健康对照参与者参加了本研究。急性躁狂期的平均胆固醇水平显著低于急性抑郁期（p < 0.025）。在急性双相躁狂中观察到血脂异常（高甘油三酯血症或低高密度脂蛋白胆固醇）的发生率最低。结论 循环脂质谱可能容易受到情感状态的影响。相对于其他情绪状态，急性躁狂状态可能伴随着与状态相关的较低胆固醇和甘油三酯水平。
