Chen Kai-Hsiang, Huang Ying-Zu
Department of Neurology, National Taiwan University Hospital Hsin-Chu Branch, Hsin-Chu.
Department of Neurology, Neuroscience Research Center, Chang Gung Memorial Hospital, Chang Gung University College of Medicine.
Neuroreport. 2018 Feb 7;29(3):214-218. doi: 10.1097/WNR.0000000000000955.
The effect of the eyes closed and eyes open states on transcranial magnetic stimulation (TMS)-induced motor cortex response remains unclear. This study evaluated the difference in TMS-induced motor cortical responses between the eyes open and eyes closed states. Ten healthy right-handed participants participated in three experiments. The stimulation-response curve of motor-evoked potential, short-interval intracortical inhibition, intracortical facilitation, and cortical silent period were determined in both the eyes open and eyes closed states, in random order. The order of performance of the eyes open and eyes closed states was also random. The stimulation-response curve obtained in the eyes open state was steeper than that obtained in the eyes closed state. The resting and active motor thresholds, cortical silent period, short-interval intracortical inhibition, and intracortical facilitation were similar in the eyes open and eyes closed states. These data demonstrate that the eyes closed state may affect the recruitment of cortical circuits and thus diminish the TMS-evoked motor output.
闭眼和睁眼状态对经颅磁刺激（TMS）诱发的运动皮层反应的影响尚不清楚。本研究评估了睁眼和闭眼状态下TMS诱发的运动皮层反应的差异。十名健康的右利手参与者参加了三项实验。以随机顺序在睁眼和闭眼状态下测定运动诱发电位的刺激-反应曲线、短间隔皮质内抑制、皮质内易化和皮质静息期。睁眼和闭眼状态的执行顺序也是随机的。睁眼状态下获得的刺激-反应曲线比闭眼状态下获得的更陡峭。睁眼和闭眼状态下的静息和主动运动阈值、皮质静息期、短间隔皮质内抑制和皮质内易化相似。这些数据表明，闭眼状态可能会影响皮质回路的募集，从而减少TMS诱发的运动输出。
