Basch R S, Grausz D, Harris N, Mitchison N A
J Natl Cancer Inst. 1979 Dec;63(6):1485-92.
The inoculation of newborn W/F, Lew, AS and DA rats with Gross murine leukemia virus (G-MuLV) resulted in the prompt appearance of cells with viral protein antigens (VPA) on their surfaces. These were first found in the bone marrow and spleen and later in the thymus gland. As the animals developed, the VPA-positive population expanded and the intensity of the fluorescence increased. In the spleen, the cells with the strongest fluorescence had the properties of T-cells, but in both spleen and bone marrow low levels of VPA were found on non-T-cells. The VPA-positive population expanded long before malignant cells could be detected and, in most animals, the entire T-cell compartment became antigen-positive. These animals were unable to respond to G-MuLV antigens and many eventually developed leukemia. However, some animals apparently broke the tolerance that followed neonatal infection and eliminated VPA-positive cells from their tissues
用格罗斯小鼠白血病病毒（G-MuLV）接种新生的W/F、刘易斯、AS和DA大鼠后，其表面迅速出现带有病毒蛋白抗原（VPA）的细胞。这些细胞最初在骨髓和脾脏中被发现，随后在胸腺中出现。随着动物的发育，VPA阳性群体扩大，荧光强度增加。在脾脏中，荧光最强的细胞具有T细胞的特性，但在脾脏和骨髓中，非T细胞上也发现了低水平的VPA。在能够检测到恶性细胞之前很久，VPA阳性群体就开始扩大，并且在大多数动物中，整个T细胞区室都变成了抗原阳性。这些动物无法对G-MuLV抗原作出反应，许多最终患上了白血病。然而，一些动物显然打破了新生儿感染后形成的耐受性，并从其组织中清除了VPA阳性细胞。
