Ludwig R, Brandeis W E, Geiger H
Klin Padiatr. 1979 Nov;191(6):540-5.
Twelve children with their first relapse of acute lymphoblastic leukemia who had the same initial therapy were treated on an out-patient basis. After 28 days all entered second remission. Medium remission duration was 11 months. At the end of the study seven patients were in continuous complete remission. Of the twelve children seven suffered bone marrow, two meningeal, two testicular relapses and one a combined bone marrow and meningeal relapse. Side effects were compatible with an out-patient treatment.
12名首次复发的急性淋巴细胞白血病患儿接受了相同的初始治疗,并在门诊接受治疗。28天后,所有患儿均进入第二次缓解期。中位缓解期为11个月。研究结束时,7名患者处于持续完全缓解状态。12名患儿中,7名发生骨髓复发,2名发生脑膜复发,2名发生睾丸复发,1名发生骨髓和脑膜联合复发。副作用与门诊治疗相符。