从[植物名称]根皮中提取的新型2-芳基苯并呋喃及其α-葡萄糖苷酶抑制活性。（原文中“from the root bark of ”后面缺少具体植物名称）

New 2-arylbenzofurans from the root bark of and their α-glucosidase inhibitory activity.

作者信息

Nuntawong Poomraphie, Kongkatitham Virunh, Likhitwitayawuid Kittisak, Mekboonsonglarp Wanwimon, Sukrong Suchada, Tanasupawat Somboon, Sritularak Boonchoo

机构信息

a Faculty of Pharmaceutical Sciences, Department of Pharmacognosy and Pharmaceutical Botany , Chulalongkorn University , Bangkok , Thailand.

b Scientific and Technological Research Equipment Centre , Chulalongkorn University , Bangkok , Thailand.

出版信息

Nat Prod Res. 2019 May;33(10):1436-1441. doi: 10.1080/14786419.2017.1419238. Epub 2017 Dec 27.

DOI:10.1080/14786419.2017.1419238

PMID:29281901

Abstract

Two new 2-arylbenzofurans, namely 13--methyllakoochin B () and artogomezianin (), were isolated from the root bark of , along with six known compounds (-). The structures of new compounds were determined by spectroscopic and chemical methods. All of the isolates were evaluated for their α-glucosidase inhibitory activity. Artogomezianin () and lakoochin A () exhibited strong α-glucosidase inhibitory activity with IC values of 18.25 and 26.19 µM, respectively, as compared with the positive control acarbose.

摘要

从[植物名称]的根皮中分离出两种新的2-芳基苯并呋喃，即13-甲基拉库钦B（[具体结构]）和阿托戈梅齐宁（[具体结构]），以及六种已知化合物（[具体结构]）。通过光谱和化学方法确定了新化合物的结构。对所有分离物进行了α-葡萄糖苷酶抑制活性评估。与阳性对照阿卡波糖相比，阿托戈梅齐宁（[具体结构]）和拉库钦A（[具体结构]）表现出较强的α-葡萄糖苷酶抑制活性，IC50值分别为18.25和26.19 μM。