一氧化二氮诱导的亚急性联合变性伴纵向广泛脊髓病及脊髓磁共振成像上的倒V征：一例报告及文献复习
Nitrous oxide induced subacute combined degeneration with longitudinally extensive myelopathy with inverted V-sign on spinal MRI: a case report and literature review.
作者信息
Yuan Jun Liang, Wang Shuang Kun, Jiang Tao, Hu Wen Li
机构信息
Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
出版信息
BMC Neurol. 2017 Dec 28;17(1):222. doi: 10.1186/s12883-017-0990-3.
BACKGROUND
Nitrous oxide (N2O), a long-standing anesthetic, is also neurotoxic by interfering with the bioavailability of vitamin B12 if abused. A few case studies have reported the neurological and psychiatric complications of N2O.
CASE PRESENTATION
Here, we reported a patient of N2O induced subacute combined degeneration (SCD) with longitudinally extensive myelopathy with inverted V-sign exhibiting progressive limb paresthesia and unsteady gait.
CONCLUSIONS
This case raises the awareness of an important mechanism of neural toxicity of N2O, and clinical physicians should be well recognized this in the field of substance-related disorders.
背景
一氧化二氮（N₂O）是一种长期使用的麻醉剂，如果滥用，它会通过干扰维生素B₁₂的生物利用度而具有神经毒性。一些病例研究报告了N₂O的神经和精神并发症。
病例报告
在此，我们报告了一例N₂O诱导的亚急性联合变性（SCD）患者，伴有纵向广泛脊髓病及倒V征，表现为进行性肢体感觉异常和步态不稳。
结论
该病例提高了对N₂O神经毒性重要机制的认识，临床医生在物质相关障碍领域应充分认识到这一点。
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