Qiu Bing, Jiang Wei, Olyaee Mojtaba, Shimura Kenji, Miyakawa Akihiro, Hu Huijing, Zhu Yongcui, Tang Lixin
Department of Gastroenterology, Heilongjiang Province Hospital, 82 Zhongshan Road, Harbin, 150036, Heilongjiang, People's Republic of China.
Department of Gastroenterology, The First Affiliated Hospital of Jiamusi University, Jiamusi, 154002, People's Republic of China.
Eur J Med Res. 2017 Dec 28;22(1):55. doi: 10.1186/s40001-017-0288-3.
Chronic hepatitis B (CHB) is the most common chronic liver disease resulting from viral infection and has become a serious threat to human health. Each year, about 1.2 million people in the world die from diseases caused by chronic infection of hepatitis B virus. The genetic polymorphism is significantly associated with the susceptibility to chronic hepatitis B. Genome-wide association study was recently developed and has become an important tool to detect susceptibility genes of CHB. To date, a number of CHB-associated susceptibility loci and regions have been identified by scientists over the world. To clearly understand the role of susceptibility loci in the occurrence of CHB is important for the early diagnosis and prevention of CHB.
慢性乙型肝炎（CHB）是病毒感染导致的最常见的慢性肝病，已成为对人类健康的严重威胁。每年，全球约有120万人死于慢性乙型肝炎病毒感染引起的疾病。基因多态性与慢性乙型肝炎的易感性显著相关。全基因组关联研究最近得到发展，已成为检测CHB易感基因的重要工具。迄今为止，世界各地的科学家已鉴定出许多与CHB相关的易感基因座和区域。清楚了解易感基因座在CHB发生中的作用对于CHB的早期诊断和预防很重要。
