Golabek Tomasz, Socha Katarzyna, Kudelski Jacek, Darewicz Barbara, Markiewicz-Zukowska Renata, Chlosta Piotr, Borawska Maria
Department of Urology, Medical College, Jagiellonian University, Krakow, Poland.
Department of Bromatology, Medical University, Bialystok, Poland.
Ann Agric Environ Med. 2017 Dec 23;24(4):602-605. doi: 10.5604/12321966.1232760. Epub 2017 May 11.
Many epidemiological and experimental studies report a strong role of chemical carcinogens in the etiology of bladder cancer. However, the involvement of heavy metals in tumourigenesis of urothelial carcinoma of the bladder has been poorly investigated. Therefore, the aim of this study was to examine the relationship between chromium (Cr) and bladder cancer.
Chromium concentration in two 36-sample series of bladder cancer tissue and sera from patients with this neoplasm were matched with those of a control group. The amount of trace elements in every tissue sample was determined using atomic absorption spectrometry. This was correlated with tumour stage.
While the median chromium concentration levels reached statistically higher values in the bladder cancer tissue, compared with the non-cancer tissue (99.632ng/g and 33.144ng/g, respectively; p<0.001), the median Cr levels in the sera of the patients with this carcinoma showed no statistical difference when compared to those of the control group (0.511μg/l and 0.710μg/l, respectively; p=0.408). The median levels of Cr in the bladder tissue, depending on the stage of the tumour, compared with the tissue without the neoplasm, observed the same relationship for both non-muscle invasive and muscle-invasive tumours (p<0.001 and p<0.01, respectively).
This study shows that patients with urothelial carcinoma of the bladder had higher tissue Cr levels than people without tumour, while no difference was found in the Cr serum levels between the two groups of patients under investigation.
许多流行病学和实验研究报告了化学致癌物在膀胱癌病因学中起重要作用。然而，重金属在膀胱尿路上皮癌肿瘤发生中的作用尚未得到充分研究。因此，本研究的目的是探讨铬（Cr）与膀胱癌之间的关系。
将两组各36份膀胱癌组织样本及该肿瘤患者血清中的铬浓度与对照组进行匹配。使用原子吸收光谱法测定每个组织样本中的微量元素含量，并将其与肿瘤分期相关联。
与非癌组织相比，膀胱癌组织中的铬浓度中位数在统计学上达到更高值（分别为99.632ng/g和33.144ng/g；p<0.001），但该癌症患者血清中的铬水平中位数与对照组相比无统计学差异（分别为0.511μg/l和0.710μg/l；p=0.408）。根据肿瘤分期，膀胱组织中的铬中位数水平与无肿瘤组织相比，非肌层浸润性和肌层浸润性肿瘤均呈现相同关系（分别为p<0.001和p<0.01）。
本研究表明，膀胱尿路上皮癌患者的组织铬水平高于无肿瘤者，而两组受调查患者的血清铬水平无差异。
