Sump Bethany, Brickner Jason H
Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA.
Genes Dev. 2017 Nov 15;31(22):2201-2203. doi: 10.1101/gad.310359.117.
Nuclear pore proteins (Nups) interact with chromosomes to regulate gene expression and chromatin structure. A new study by Franks and colleagues (pp. 2222-2234) provides new mechanistic insight into the molecular basis by which Nup98 promotes gene activation in normal hematopoietic cells and how that process is altered by translocations to cause excess expression of developmental genes in leukemia.
核孔蛋白（Nups）与染色体相互作用以调节基因表达和染色质结构。弗兰克斯及其同事的一项新研究（第2222 - 2234页）为Nup98在正常造血细胞中促进基因激活的分子基础以及该过程如何因易位而改变，从而导致白血病中发育基因过度表达提供了新的机制性见解。
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