人类疾病中核孔复合物的研究进展。
Advances in the understanding of nuclear pore complexes in human diseases.
机构信息
The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315040, Zhejiang, China.
Department of Biochemistry and Molecular Biology, and Zhejiang Key Laboratory of Pathophysiology, Health Science Center, Nngbo University, Ningbo, 315211, Zhejiang, China.
出版信息
J Cancer Res Clin Oncol. 2024 Jul 30;150(7):374. doi: 10.1007/s00432-024-05881-5.
BACKGROUND
Nuclear pore complexes (NPCs) are sophisticated and dynamic protein structures that straddle the nuclear envelope and act as gatekeepers for transporting molecules between the nucleus and the cytoplasm. NPCs comprise up to 30 different proteins known as nucleoporins (NUPs). However, a growing body of research has suggested that NPCs play important roles in gene regulation, viral infections, cancer, mitosis, genetic diseases, kidney diseases, immune system diseases, and degenerative neurological and muscular pathologies.
PURPOSE
In this review, we introduce the structure and function of NPCs. Then We described the physiological and pathological effects of each component of NPCs which provide a direction for future clinical applications.
METHODS
The literatures from PubMed have been reviewed for this article.
CONCLUSION
This review summarizes current studies on the implications of NPCs in human physiology and pathology, highlighting the mechanistic underpinnings of NPC-associated diseases.
背景
核孔复合物（NPCs）是一种复杂而动态的蛋白质结构，跨越核膜，充当核质间分子运输的守门员。NPCs 由多达 30 种不同的蛋白质组成，称为核孔蛋白（NUPs）。然而，越来越多的研究表明，NPCs 在基因调控、病毒感染、癌症、有丝分裂、遗传疾病、肾脏疾病、免疫系统疾病以及退行性神经和肌肉病理中发挥重要作用。
目的
在这篇综述中，我们介绍了 NPCs 的结构和功能。然后，我们描述了 NPCs 每个成分的生理和病理作用，为未来的临床应用提供了方向。
方法
本文综述了来自 PubMed 的文献。
结论
本综述总结了 NPCs 在人类生理学和病理学中的意义的当前研究，强调了 NPC 相关疾病的机制基础。
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