Jing Yuchao, Liu Haofei, Xu Wenwen, Yang Qian
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China.
Exp Ther Med. 2017 Dec;14(6):6069-6073. doi: 10.3892/etm.2017.5282. Epub 2017 Oct 11.
Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Current IBD treatments have poor tolerability and insufficient therapeutic efficacy, thus, alternative therapeutic approaches are required. Recently, a number of dietary supplements have emerged as promising interventions. In the present study oral administration of a carotenoid (4,4'-diaponeurosporene)-producing markedly ameliorated dextran sulfate sodium salt-induced mouse colitis, as demonstrated by a reduction in weight loss and the severity of bleeding, which indicated that 4,4'-diaponeurosporene may have beneficial effects on treatments for colitis. This preliminary study indicated that 4,4'-diaponeurosporene may function synergistically with probiotics to provide a novel and effective strategy to prevent colitis.
炎症性肠病（IBD）是一种胃肠道的慢性复发性炎症性疾病。目前的IBD治疗耐受性差且治疗效果不足，因此需要替代治疗方法。最近，一些膳食补充剂已成为有前景的干预措施。在本研究中，口服一种产生类胡萝卜素（4,4'-二脱辅基神经孢子烯）的物质可显著改善葡聚糖硫酸钠诱导的小鼠结肠炎，体重减轻和出血严重程度降低表明了这一点，这表明4,4'-二脱辅基神经孢子烯可能对结肠炎治疗有有益作用。这项初步研究表明，4,4'-二脱辅基神经孢子烯可能与益生菌协同发挥作用，为预防结肠炎提供一种新的有效策略。
