Zhou Xiaojun, Liu Qiang, Wada Youichiro, Liao Lin, Liu Ju
Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.
Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.
Oncol Lett. 2018 Jan;15(1):183-188. doi: 10.3892/ol.2017.7282. Epub 2017 Oct 26.
CDKN1A-interacting zinc finger protein 1 (CIZ1), a nuclear protein that participates in DNA replication, is involved in the pathogenesis of several types of cancer. However, the role of CIZ1 in lung squamous cell carcinoma (LSCC) is not fully understood. In the present study, the expression of CIZ1 in tissue microarrays and surgical samples of human LSCCs was examined. CIZ1 expression was found to be significantly increased in LSCC tissues compared with adjacent tissues or normal controls, whereas expression of a CIZ1-interacting protein, p21, was decreased. CIZ1 staining intensity and CIZ1-positive vascular invasion were positively correlated with at least two categories of the Tumor-Node-Metastasis (TNM) staging system (T stage, N stage or TNM stage). It was also observed that CIZ1 was specifically expressed in the vascular cells of LSCC tissues. These results indicate that overexpression of CIZ1 may contribute to the growth and angiogenesis of LSCC, thus CIZ1 could represent a biomarker for diagnosis and a target for therapeutic intervention.
细胞周期蛋白依赖性激酶1A相互作用锌指蛋白1（CIZ1）是一种参与DNA复制的核蛋白，与多种癌症的发病机制有关。然而，CIZ1在肺鳞状细胞癌（LSCC）中的作用尚未完全明确。在本研究中，检测了CIZ1在人LSCC组织芯片及手术样本中的表达情况。结果发现，与相邻组织或正常对照相比，LSCC组织中CIZ1的表达显著增加，而与CIZ1相互作用的蛋白p21的表达则降低。CIZ1染色强度及CIZ1阳性血管侵犯与肿瘤-淋巴结-转移（TNM）分期系统的至少两类分期（T分期、N分期或TNM分期）呈正相关。还观察到CIZ1在LSCC组织的血管细胞中特异性表达。这些结果表明，CIZ1的过表达可能促进LSCC的生长和血管生成，因此CIZ1可能成为诊断生物标志物及治疗干预靶点。
