（此处原文不完整，缺少具体基因等相关内容）中的功能多态性与中国人群的胃癌风险相关。
Functional polymorphisms in are associated with gastric cancer risk in Chinese population.
作者信息
Gu Yayun, Deng Bin, Kong Jing, Yan Caiwang, Huang Tongtong, Yang Jianshui, Wang Yan, Wang Tianpei, Qi Qi, Jin Guangfu, Du Jiangbo, Ding Yanbing, Liu Li
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China.
出版信息
Oncotarget. 2017 Oct 27;8(62):105312-105319. doi: 10.18632/oncotarget.22172. eCollection 2017 Dec 1.
Recently promoter of has been found to be high methylated in gastric cancer tissues which might be involved in the initiation of gastric carcinoma development. To test whether the variants in could modify the risk of gastric cancer, we evaluated the association between four SNPs (rs6194, rs12521436, rs33388 and rs4912913) in and gastric cancer risk in a case-control study with 1,113 gastric cancer cases and 1,848 cancer-free controls in a Chinese population. We found a significant association between rs4912913 and gastric cancer risk (OR=1.18, 95%CI=1.05-1.33, =5.49×10). We also observed that the A-allele of rs12521436 and rs33388 were significantly associated with a decreased risk of gastric cancer (OR=0.84, 95%CI=0.76-0.94, =2.78×10; OR=0.85, 95%CI=0.75-0.97; =0.018). Finally, we made a joint effect analysis of rs12521436, rs33388 and rs4912913 on risk of gastric cancer ( =2.83×10). These findings indicate that the variants rs4912913, rs33388 and rs12521436 of may contribute to gastric cancer susceptibility.
最近发现，[具体基因名称]的启动子在胃癌组织中高度甲基化，这可能参与了胃癌的发生发展。为了检验[具体基因名称]中的变异是否会改变胃癌风险，我们在一项病例对照研究中评估了[具体基因名称]的四个单核苷酸多态性（rs6194、rs12521436、rs33388和rs4912913）与胃癌风险之间的关联，该研究纳入了1113例胃癌病例和1848例无癌对照的中国人群。我们发现rs4912913与胃癌风险之间存在显著关联（OR = 1.18，95%CI = 1.05 - 1.33，P = 5.49×10）。我们还观察到，rs12521436和rs33388的A等位基因与胃癌风险降低显著相关（OR = 0.84，95%CI = 0.76 - 0.94，P = 2.78×10；OR = 0.85，95%CI = 0.75 - 0.97；P = 0.018）。最后，我们对rs12521436、rs33388和rs4912913对胃癌风险的联合效应进行了分析（P = 2.83×10）。这些发现表明，[具体基因名称]的rs4912913、rs33388和rs12521436变异可能与胃癌易感性有关。
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