Bildsoe M C, Moradian G P, Hunter D W, Castaneda-Zuniga W R, Amplatz K
Department of Radiology, University of Minnesota Hospital and Clinic, Minneapolis 55455.
Radiology. 1989 Apr;171(1):231-3. doi: 10.1148/radiology.171.1.2928529.
The authors present preliminary data on in vitro mechanical clot dissolution by means of a catheter with a tiny high-speed propeller enclosed in a special housing. Preweighed human blood clots were subjected to the catheter in a test tube with saline at various propeller speeds and durations of application. After filtration of the resultant slurry, the clot residue was weighed and examined histologically. Clot dissolution was found to be related to both the duration and speed of propeller rotation. No fibrin residue was seen after dissolution, although potential embolic material, composed of clumps of cellular debris as large as 208 microns in longest dimension, was found. Mechanical clot dissolution could possibly be used in any natural or synthetic blood vessel in which there is acute or subacute thrombosis, with fewer complications and lower cost than obtained with traditional methods.
作者展示了关于通过一种导管进行体外机械性血栓溶解的初步数据，该导管带有一个封闭在特殊外壳中的微型高速螺旋桨。将预先称重的人体血凝块置于装有盐水的试管中，使导管以不同的螺旋桨速度和作用时间作用于血凝块。对所得浆液进行过滤后，对血凝块残渣进行称重并进行组织学检查。发现血栓溶解与螺旋桨旋转的持续时间和速度均有关。溶解后未见纤维蛋白残渣，不过发现了潜在的栓塞物质，其由最长尺寸达208微米的细胞碎片团块组成。机械性血栓溶解可能适用于任何存在急性或亚急性血栓形成的天然或人造血管，与传统方法相比，并发症更少且成本更低。
