癌胚抗原（CEA）升高与复发性直肠癌患者较差的生存率相关。
Elevated CEA is associated with worse survival in recurrent rectal cancer.
作者信息
Cho Won Kyung, Choi Doo Ho, Park Hee Chul, Park Won, Yu Jeong Il, Park Young Suk, Park Joon Oh, Lim Ho Yeong, Kang Won Ki, Kim Hee Cheol, Cho Yong Beom, Yun Seong Hyeon, Lee Woo Yong
机构信息
Department of Radiation Oncology, Seoul, Republic of Korea.
Division of Hematology-Oncology, Department of Medicine, Seoul, Republic of Korea.
出版信息
Oncotarget. 2017 Nov 18;8(62):105936-105941. doi: 10.18632/oncotarget.22511. eCollection 2017 Dec 1.
This study investigated the prognostic impact of serum carcinoembryonic antigen (CEA) level in recurrent rectal cancer. We reviewed 745 patients who developed recurrence after curative treatment for rectal cancer between January 2000 and December 2012. Multivariate analyses for survival revealed that age > 60 years ( = 0.005), r-CEA ≥ 5 ng/ml ( < 0.001), disease free interval (DFI) < 12 months ( < 0.001), and palliative or conservative treatment ( < 0.001) were unfavorable factors.
本研究调查了血清癌胚抗原（CEA）水平对复发性直肠癌的预后影响。我们回顾了2000年1月至2012年12月期间745例直肠癌根治性治疗后出现复发的患者。生存的多因素分析显示，年龄>60岁（P = 0.005）、复发时CEA≥5 ng/ml（P < 0.001）、无病间期（DFI）<12个月（P < 0.001）以及姑息或保守治疗（P < 0.001）是不利因素。
Zotero 插件