Cooreman J, Levallois M, Redon S, Perdrizet S
Institut National de la Santé et de la Recherche Médicale, Unité 179, Le Vésinet.
Rev Mal Respir. 1989;6(1):65-70.
The object of this work was to study the relationship between chronic cough in adolescence, and chronic symptoms and airflow obstruction in adults. The data were collected between 1982 and 1984 from 1807 men and women living in Bordeaux (France) and its surrounds. A self administered questionnaire was used which focused on current respiratory symptoms and respiratory symptoms during adolescence. Spirometric curves (FVC, FEV1 and FEF 25-75) were measured. The population was evenly split between men (mean age 40.1) and women (mean age 38.6). Most subjects were French; more than half were non smokers; all socioprofessional categories were represented except farmers, craftsmen and merchants. The proportion of subjects with current respiratory symptoms was 2 to 10 times higher amongst subjects with respiratory symptoms during their adolescence than in those who had none. The relationships were highly significant and remained so after adjustments for the confounding factors following: sex, age, nationality, socio-economic status, smoking habits, occupational exposure and previous occupational disease. Mean spirometric values were higher amongst subjects without chronic cough during their adolescence than those who had cough. Differences were significant for FVC, FEV1, FEF 25-75 in women and were on the borderline for FEF 25-75 in men. This study showed that respiratory conditions in adolescence represent an important risk factor for chronic symptoms and airflow obstruction in adult life.
这项研究的目的是探讨青少年慢性咳嗽与成人慢性症状及气流受限之间的关系。研究数据于1982年至1984年间收集,来自居住在法国波尔多及其周边地区的1807名男性和女性。采用了一份自我填写的问卷,重点关注当前的呼吸道症状以及青少年时期的呼吸道症状。测量了肺活量曲线(FVC、FEV1和FEF 25-75)。研究人群中男性(平均年龄40.1岁)和女性(平均年龄38.6岁)人数均等。大多数受试者为法国人;超过一半不吸烟;除农民、工匠和商人外,涵盖了所有社会职业类别。青少年时期有呼吸道症状的受试者中,当前有呼吸道症状的比例比无此类症状者高出2至10倍。在对性别、年龄、国籍、社会经济地位、吸烟习惯、职业暴露和既往职业病等混杂因素进行调整后,这些关系仍然高度显著。青少年时期无慢性咳嗽的受试者的平均肺活量值高于有咳嗽者。女性在FVC、FEV1、FEF 25-75方面差异显著,男性在FEF 25-75方面接近显著水平。这项研究表明,青少年时期的呼吸道状况是成年后慢性症状和气流受限的重要危险因素。