Workman Alan D, Farquhar Douglas R, Brody Robert M, Parasher Arjun K, Carey Ryan M, Purkey Michael T, Nagda Danish A, Brooks John S, Hartner Lee P, Brant Jason A, Newman Jason G
Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Head Neck. 2018 Apr;40(4):756-762. doi: 10.1002/hed.25054. Epub 2017 Dec 29.
Leiomyosarcoma is a rare neoplasm of the head and neck. The purpose of this study was to present our single-institution case series of head and neck leiomyosarcoma and a review of cases in the National Cancer Data Base (NCDB).
Patients with head and neck leiomyosarcoma at the University of Pennsylvania and in the NCDB were identified. Demographic characteristics, tumor factors, treatment paradigms, and outcomes were evaluated for prognostic significance.
Nine patients with head and neck leiomyosarcoma from the institution were identified; a majority had high-grade disease and cutaneous leiomyosarcoma, with a 5-year survival rate of 50%. Two hundred fifty-nine patients with leiomyosarcoma were found in the NCDB; macroscopic positive margins and high-grade disease were associated with poor prognosis (P < .01), and positive surgical margins were related to adjuvant radiation (P < .001).
Head and neck leiomyosarcoma presents at a high grade and is preferentially treated with surgery. Several demographic and tumor-specific factors are associated with outcomes and prognosis.
平滑肌肉瘤是一种罕见的头颈部肿瘤。本研究的目的是展示我们单机构的头颈部平滑肌肉瘤病例系列，并对国家癌症数据库（NCDB）中的病例进行回顾。
确定宾夕法尼亚大学和NCDB中患有头颈部平滑肌肉瘤的患者。评估人口统计学特征、肿瘤因素、治疗模式和结局的预后意义。
该机构确定了9例头颈部平滑肌肉瘤患者；大多数患者患有高级别疾病和皮肤平滑肌肉瘤，5年生存率为50%。在NCDB中发现了259例平滑肌肉瘤患者；大体切缘阳性和高级别疾病与预后不良相关（P <.01），手术切缘阳性与辅助放疗相关（P <.001）。
头颈部平滑肌肉瘤多为高级别，首选手术治疗。一些人口统计学和肿瘤特异性因素与结局和预后相关。
