Department of Chemistry, Bogazici University, Bebek, 34342, Istanbul, Turkey.
Center for Life Sciences and Technologies, Bogazici University, Istanbul, Turkey.
Chem Rec. 2018 Jun;18(6):570-586. doi: 10.1002/tcr.201700060. Epub 2017 Dec 29.
Functional polymers are widely employed in various areas of biomedical sciences. In order to tailor them for desired applications, facile and efficient functionalization of these polymeric materials under mild and benign conditions is important. Polymers containing reactive maleimide groups can be employed for such applications since they provide an excellent handle for conjugation of thiol- and diene-containing molecules and biomolecules. Until recently, fabrication of maleimide containing polymeric materials has been challenging due to the interference from the highly reactive double bond. A Diels-Alder/retro Diels-Alder reaction sequence based strategy to transiently mask the maleimide group provides access to such polymeric materials. In this personal account, we summarize contributions from our group towards the fabrication and functionalization of maleimide-containing polymeric materials over the past decade.
功能高分子在生物医学科学的各个领域得到广泛应用。为了使它们适用于预期的应用，在温和、良性的条件下对这些高分子材料进行简单高效的功能化非常重要。含有反应性马来酰亚胺基团的聚合物可用于此类应用，因为它们为含有巯基和二烯的分子和生物分子的共轭提供了极好的处理方法。直到最近，由于高反应性双键的干扰，制造含马来酰亚胺的聚合材料一直具有挑战性。基于 Diels-Alder/retro Diels-Alder 反应序列的策略来暂时掩蔽马来酰亚胺基团，为获得此类聚合材料提供了途径。在这篇个人述评中，我们总结了过去十年中我们小组在含马来酰亚胺的聚合材料的制造和功能化方面的贡献。
